NIGMS (and other NIH) investigators previously have been able to obtain over 2,500 knockout mouse strains at a negotiated cost from Lexicon. These mouse strains are no longer available directly through Lexicon.
You may now request them, along with an additional 1,000 knockout strains, through Taconic. NIH investigators acquiring a Lexicon knockout mouse through Taconic are expected to place the mouse lines in a NIH-supported mouse repository.
The NIH Guide notice updates the policy and provides more details.
Our research programs often produce valuable scientific resources. But if one of these initiatives ends, then what becomes of the resource it generated?
To address this issue, we formed a committee of NIGMS staff to explore options for maintaining scientific resources resulting from NIGMS-supported research. We defined a resource as a non-hypothesis-driven activity to provide data, materials, tools or services that are essential to making the most timely, high-quality and cost-efficient progress in a field. We proposed principles for continuing support of “legacy” resources that are of great benefit to researchers working within the Institute’s mission areas.
Based on our discussions, we recommended that NIGMS pilot a limited program to fund the maintenance of existing, high-value resources. The NIGMS Council approved the concept in May, and the funding opportunity announcement just appeared in the NIH Guide. Applications are due once per year in October.
If you are interested in applying, read the announcement for details, including the special eligibility requirements. And before you apply, be sure to contact the appropriate NIGMS division director to discuss your ideas.
We hope that the results of this limited pilot program will help guide future decisions about maintaining important research-generated resources.
The program announcement for NIGMS program project grants was published yesterday in the NIH Guide. This grant mechanism enables outstanding scientists working on different aspects of a similar problem to collaborate.
Applicants should propose innovative, complementary approaches to solving a significant biological question within the NIGMS mission. Over a 5-year period, program projects may receive total direct costs of up to $6.5 million (excluding any proposed equipment purchases and subcontract indirect costs). If you request more than $500,000 in direct costs in any year, you must receive approval from NIGMS staff before submitting your proposal.
I strongly encourage you to speak to the relevant program staff member before submitting a P01 application. For more information, see the NIGMS Program Project Funding Policies Web site.
NIH announced this week that the 2-day “error correction window” to fix NIH system-identified errors or warnings after the submission deadline is being eliminated (see NOT-OD-10-123). This change will take effect for submission deadlines on or after January 25, 2011. You will still have up to 2 business days to view the application image and submit a corrected/changed application, as long as you do so before the deadline.
The error correction window was instituted by NIH as a temporary measure to facilitate the transition from paper to electronic applications.
In light of this change and another related to post-submission materials, it is really important to make sure that you submit an application early (before the submission deadline) so that you and your signing official have an opportunity to address any errors or warnings.
NIH’s Applying Electronically Web site includes many helpful resources, such as tips for avoiding common errors.
If you’ve got an exceptionally innovative idea that has the potential to jump-start a field, take a look at this year’s EUREKA funding opportunity announcement. Wondering whether EUREKA is appropriate for what you want to do? Check out the Frequently Asked Questions (Link no longer active). If your question isn’t there, ask me!
If you do decide to apply, start working on that application right away, because this year’s receipt deadline is October 21, 2010—a month earlier than last year’s deadline.
NIGMS has re-announced the Research on Interventions (R01) program that supports research on efforts to increase student interest, motivation and preparedness for careers in biomedical and behavioral research. Proposed research should test assumptions and hypotheses regarding social and behavioral factors that might inform and guide interventions.
We are particularly interested in interventions that are specifically designed to increase the number of students from underrepresented groups entering careers in biomedical and behavioral sciences. However, you need not restrict proposed research to students from these groups. In fact, comparative research that analyzes the experience of all groups can help us understand how interventions should be tailored to make more underrepresented students successful in biomedical and behavioral careers.
We strongly encourage collaboration among biomedical, behavioral and social science researchers.
Currently funded projects are quite varied. Examples include research on interventions at the institutional level and on student characteristics, such as self-efficacy and leadership.
Letters of intent are due September 15, 2010, and applications are due October 15, 2010. For additional information about the program, see the funding opportunity announcement or contact me at 301-594-3900 or firstname.lastname@example.org.
NIGMS recently announced plans to continue participating in the Joint DMS/NIGMS Initiative to Support Research at the Interface of the Biological and Mathematical Sciences. The NSF solicitation includes more information about applying.
This joint NSF/NIGMS program started in 2002 to address the pressing need to bring mathematicians into the core of biological research and to encourage broader use of innovative mathematics in understanding life processes. Since then, NIGMS has funded 90 projects involving more than 150 investigators. This year’s awards included nine grants to support mathematics-driven research in biomolecular interactions, signaling and regulatory pathway dynamics, cell proliferation and stress response and branched morphogenesis.
Applications for the program are accepted once a year. The 2010 deadline is October 1. A joint NSF/NIGMS panel reviews the applications, and a group of NSF and NIGMS program directors selects ones for funding. The typical funding level for a 4-year grant is between $1.2 million and $1.6 million (total costs for all years).
In April of this year, NSF and NIGMS sponsored the Frontiers in Mathematical Biology meeting, which brought together scientists supported by the program. See my May 5 post for more about this meeting.
The August issue of NIH’s Extramural Nexus includes two announcements that might interest you.
Impact Score Paragraph in Summary Statements
Starting with September grant application reviews, reviewers will include a summary paragraph to explain what factors they considered in assigning the overall impact score. This should help investigators better understand the reasons for the score.
Plain Language in Public Sections of Grant Applications
The director’s column talks about the importance of communicating research value in your grant application.
Your grant title, abstract and statement of public health relevance are very important. Once a grant is funded, these items are available to the public through NIH’s RePORTER database. Many people are interested in learning about research supported with taxpayer dollars, so I encourage you to be clear and accurate in writing these parts of your application. Reviewers are being told to expect plain language in these sections.
The Nexus column includes links to these helpful resources: