Metabolomics, Human DNA Sequence Variants Funding Opportunities

You may be interested in the following funding opportunity announcements:

Collaborative Activities to Promote Metabolomics Research (Admin Supp)
(PA-13-041)

Purpose: Request supplemental funds to current NIH-funded research projects for new interactive collaborations between basic or clinical researchers and metabolomics experts to pursue biomedical studies requiring a metabolomics approach
Application due date: March 15, 2013
NCI contact: Barbara Spalholz, 301-496-7028

New Methods for Understanding the Functional Role of Human DNA Sequence Variants in Complex Phenotypes (R01)
(RFA-GM-14-006)

Purpose: Propose experimental approaches for determining the functional relevance of human DNA sequence variants
Letter of intent due date: January 21, 2013
Application due date: February 21, 2013
NIGMS contact: Donna Krasnewich, 301-594-0943

Crystallography Gets Support from United Nations, NIGMS

Laue X-ray diffraction pattern of a single crystal of a dimeric hemoglobin taken at the BioCARS structural biology research center. Credit: Vukica Srajer, BioCARS/University of Chicago, and William Royer, Jr., University of Massachusetts Medical School
Laue X-ray diffraction pattern of a single crystal of a dimeric hemoglobin taken at the BioCARS structural biology research center. Credit: Vukica Srajer, BioCARS/University of Chicago, and William Royer, Jr., University of Massachusetts Medical School

As NIH Director Francis Collins recently noted on his blog, this year marks the 100th anniversary of the first experiment demonstrating that X-rays are diffracted by crystals. Two years later, this discovery was recognized with a Nobel Prize in physics. For this and other reasons, the United Nations has designated 2014 as the International Year of Crystallography Exit icon. The designation offers an opportunity for organizations worldwide to increase public awareness of the field and promote access to crystallographic knowledge and activities.

X-ray crystallography is central to many areas of basic biomedical research, and NIGMS supports a number of major crystallographic efforts that may be of interest and use to you.

Since 2000, our Protein Structure Initiative (PSI) has undertaken the high-throughput determination of protein structures by crystallography and NMR methods, resulting in the deposition in the public Protein Data Bank Exit icon of more than 5,000 macromolecular structures. The initiative’s current phase focuses on the determination of biologically relevant and important structures. Members of the scientific community can nominate proteins Exit icon for structure determination, order protein plasmids and empty vectors Exit icon, and access PSI data and other resources Exit icon. Active PSI funding opportunities solicit applications for Technology Development for High-Throughput Structural Biology Research (R01) and Technology Development for Protein Modeling (R01).

We also have been involved in supporting the construction, upgrade and maintenance of synchrotron beamline stations for X-ray crystallographic studies. These activities include a state-of-the-art facility Exit icon at the Advanced Photon Source at Argonne National Laboratory, which we established in partnership with the National Cancer Institute. Our support of synchrotron facilities and of crystallographic technology development has improved access for NIH grantees and other users and increased the capacity for crystallographic data collection.

In addition, we now oversee the Biomedical Technology Research Centers, several of which focus on developing and applying innovative crystallography techniques. These resource centers provide broad access to instruments, methods, software, expertise and hands-on training.

I look forward to sharing more details about the International Year of Crystallography as activities get under way.

NIGMS Support of Career Development (K) Awards

NIH offers a wide variety of career development (K) awards, and NIGMS participates in a number of them. Here are answers to questions we often get about NIGMS support of these awards.

Which career development awards (K awards) does NIGMS support?

We support:

I’ve found a new funding opportunity announcement (FOA) for a K award. How can I tell if NIGMS participates in this FOA?

If NIGMS is participating, it will be listed in the “Components of Participating Organizations” section near the top of the FOA. If NIGMS is not participating, consider whether another listed component may be appropriate for your application.

Where can I learn more about NIGMS-supported K awards?

Visit our Mentored Career Development Awards page to find additional information about most of our K awards. You also can contact an NIGMS program director in your area of interest.

Where can I find information on all NIH K awards?

You can find information on these awards at the K Kiosk. Another NIH resource, the Career Award Wizard, can help you identify the K awards that may be right for you.

How to Use RePORTER When Preparing New Grant Applications

NIH offers two tools that can help you search for projects similar to the one you’re thinking about. In this post, I’ll take you on a quick tour of the NIH RePORTER tool, a repository of information about NIH-funded research projects, and show you how to find information that may be useful to know before you start writing a grant application. A future Feedback Loop post will cover the thesaurus-based search tool called Like This.

Main Query Form

From RePORTER’s Main Query Form, you can search by principal investigator name, project number, organization, text term(s) and many other criteria.

If you want to know which NIH institutes or centers fund projects like yours, or which study section would be most appropriate to review your application, then searching by text term(s) would probably be the best approach.

To find projects in a particular research area, you may start with the “Advanced” text query option, which allows for complex queries using the Boolean operators “and,” “or,” and “not” along with parentheses for nesting phrases. The example below searches for projects on telomeres and their relationship to cancer using wildcards (%) and synonyms to encompass variations such as telomere, telomerase, neoplasm, neoplastic, etc.

Text search box

TIP: One way to limit the number of search results is to use the Funding Mechanism field on the Main Query Form to select the mechanism(s) most relevant to your particular search (e.g., “Research Project Grants” or “Training, Individual”). If you already have a funding mechanism in mind, you can type R01, R21, F33, etc., into that part of the Project Number field.

Once you have entered your search and submitted the query, you’ll get a Project Search Results page, which displays the grant number, project title, principal investigator’s name and organization, NIH funding institute or center, and fiscal year total cost.

Project Information Details Page

To get specific information about a particular project listed on the Project Search Results page, click on its Project number (e.g., GM066228). You’ll get the Project Information Details page that lists the grant’s program official with contact information, the study section that reviewed the application, and the funding opportunity announcement (FOA) to which the application responded.

By viewing the details of projects most relevant to yours, you can begin to get a sense of which program director(s) to contact to discuss your potential application, which study sections review applications like yours, and whether applications in this area typically respond to a parent FOA or a special initiative.

Other Project Information Page Tabs

From the Project Information Details page, you can use the tabs near the top to get to pages with other information relevant to your search. For example, the Description tab takes you to the grant abstract. Reading these can help you become familiar with other funded projects in your interest area and help you identify and highlight what’s unique about your proposal. The Similar Projects and Nearby Projects tabs offer additional ways to find grants related to your search term and to find potential collaborators.

TIP: To refine your original search term on the Main Query Form, use the results from the Similar Projects tab to identify alternative phrases in project titles and abstracts that can increase the effectiveness of your text search.

Data & Visualize Tab

Another feature, available from the Project Search Results page, is a tab called Data & Visualize. This provides a graph of the NIH institutes or centers that administer research in that area and their levels of support. The table next to the bar chart lets you drill down to see projects by funding component.

Data and visualize graph

Comments Welcome

I hope this sampling has introduced you to some useful ways of exploring the NIH-funded research portfolio. We continue to make RePORTER faster, easier to use, and more informative, and we welcome your comments and suggestions, including topics for other RePORTER tutorials. Send them to RePORT@mail.nih.gov or directly to me at onkenj@od.nih.gov.