Small Business Opportunities for Stem Cell-Based Regenerative Medicine, Behavioral and Social Sciences Course Development

You may be interested in these recent funding opportunity announcements:

Improvement of Animal Models and Development of Technologies for Stem Cell-Based Regenerative Medicine (SBIR)(R43/R44)
(PA-13-223)

Purpose: Develop or improve animal models and/or technologies for obtaining, characterizing and testing animal and human stem cells and their derivatives for regenerative medicine
Application due date: Standard dates apply
NIGMS contact: Stefan Maas, 301-594-0943

Improvement of Animal Models and Development of Technologies for Stem Cell-Based Regenerative Medicine (STTR)(R41/R42)
(PA-13-224)

Purpose: Develop or improve animal models and/or technologies for obtaining, characterizing and testing animal and human stem cells and their derivatives  for  regenerative medicine
Application due date: Standard dates apply
NIGMS contact: Stefan Maas, 301-594-0943

Short Courses on Innovative Methodologies in the Behavioral and Social Sciences (R25)
(RFA-OD-13-009)

Purpose: Develop, implement, evaluate and disseminate short courses in innovative methods for behavioral and social sciences research
Letter of intent due date: June 3, 2013
Application due date: July 3, 2013
NIGMS contact: Stephen Marcus, 301-451-6446

Budget Outlook for Fiscal Year 2013 and Beyond

As a result of the sequestration, the NIGMS full-year appropriation for Fiscal Year 2013 was reduced by about 5% compared to Fiscal Year 2012. This reduction brings our operating budget to $2,291,294,437. Our financial management plan outlines the Institute’s fiscal policies, which are consistent with NIH’s policies:

Research Project Grants (RPGs)

  • Inflationary increases will be discontinued for all competing and noncompeting awards (both modular and nonmodular).
  • All noncompeting grants will be reduced by 3.5% from the Fiscal Year 2013 committed level. Commitments in Fiscal Year 2014 and beyond will remain unchanged.
  • Overall average costs for competing RPGs will be at approximately the Fiscal Year 2012 level. Inflationary increases for future-year commitments will be discontinued.
  • Fiscal Year 2013 noncompeting awards that have already been issued at a reduced level will be revised upward to reflect the 3.5% reduction.
  • New investigators on R01-equivalent awards will be supported at a success rate equivalent to that of established investigators submitting new (Type 1) R01-equivalent applications.

Ruth L. Kirschstein National Research Service Awards

  • The stipend levels established in Fiscal Year 2012 will be continued this fiscal year.

Centers and Other Mechanisms

  • Noncompeting awards will be reduced by 3.5% from the initial Fiscal Year 2013 committed level.

Fiscal Year 2012 R01 Funding Outcomes

Fiscal Year 2012 ended on September 30, 2012. As in previous years, we have analyzed the funding results (including percentiles and success rates) for R01 grants, shown in Figures 1-5. Thanks to Jim Deatherage for preparing these data again this year.

Figure 1. Competing R01 applications reviewed (open rectangles) and funded (solid bars) in Fiscal Year 2012.
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Figure 1. Competing R01 applications reviewed (open rectangles) and funded (solid bars) in Fiscal Year 2012.

Figure 2. NIGMS competing R01 funding curves for Fiscal Years 2008-2012. For Fiscal Year 2012, the success rate for R01 applications was 25%, and the midpoint of the funding curve was at approximately the 20th percentile.
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Figure 2. NIGMS competing R01 funding curves for Fiscal Years 2008-2012. For Fiscal Year 2012, the success rate for R01 applications was 25%, and the midpoint of the funding curve was at approximately the 20th percentile.

In Fiscal Year 2012, there was a slight improvement in success rate. This is due in part to the relatively flat number of competing applications that we received (Figure 4).

Figure 3. Number of R01 and R37 grants (competing and noncompeting) funded in Fiscal Years 1998-2012.
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Figure 3. Number of R01 and R37 grants (competing and noncompeting) funded in Fiscal Years 1998-2012.

Figure 4. Number of competing R01 applications (including resubmissions) received during Fiscal Years 1998-2012.
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Figure 4. Number of competing R01 applications (including resubmissions) received during Fiscal Years 1998-2012.

Below are the total NIGMS expenditures (including both direct and indirect costs) for R01 and R37 grants for Fiscal Year 1996 through Fiscal Year 2012.

Figure 5. The upper curve shows the overall NIGMS expenditures on R01 and R37 grants (competing and noncompeting, including supplements) in Fiscal Years 1996-2012. The lower curve (right vertical axis) shows the median direct costs of NIGMS R01 grants. Results are in actual dollars with no correction for inflation.
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Figure 5. The upper curve shows the overall NIGMS expenditures on R01 and R37 grants (competing and noncompeting, including supplements) in Fiscal Years 1996-2012. The lower curve (right vertical axis) shows the median direct costs of NIGMS R01 grants. Results are in actual dollars with no correction for inflation.