While it is well recognized that an individual’s microbiome has a substantial influence on health, fundamental knowledge gaps remain regarding host-microbial interactions, especially those involving the effects of probiotic and prebiotic products. To stimulate research in this area, NIGMS is participating with a number of other NIH institutes and centers in a new funding opportunity announcement (FOA), Advancing Mechanistic Probiotic/Prebiotic and Human Microbiome Research (R01).
We are looking for biochemists, chemists, bioengineers, systems biologists and others to define biochemical pathways, small molecules and biologics in host-microbial interactions. We are particularly interested in applications from interdisciplinary teams that propose to provide a functional and mechanistic picture of host-microbial ecosystems. This includes an understanding of host-probiotic-microbial interactions and the effect of exogenous molecules such as prebiotics on these interactions. We also encourage the development of computational models, tools and technologies that enable the prediction, identification, quantification and characterization of host-microbial dynamics as well as the development of tractable host-microbial systems.
This FOA is a program announcement with no set-aside funds. Standard R01 due dates apply, so the first receipt date is June 5. Although a letter of intent is not required, we recommend that you contact us (e-mail Barbara in the Division of Pharmacology, Physiology, and Biological Chemistry or e-mail Darren in the Division of Genetics and Developmental Biology) to discuss your potential proposal and NIGMS-specific FOA guidelines.
NIGMS Director Jon Lorsch and I will field your questions about the recently announced Maximizing Investigators’ Research Award (MIRA) (R35) during a webinar on Thursday, Feb. 19, from 2-3 p.m. EST. You’ll be able to access the webinar at https://webmeeting.nih.gov/nigmsmira/. During the event, you can submit questions by calling 301-451-4301 or e-mailing me. You also can send questions to me ahead of time.
Since announcing this new funding opportunity, we’ve received many inquiries. The most common questions have concerned eligibility, so we created a flowchart to help you determine this. Our MIRA Answers to Frequently Asked Questions offer additional details about eligibility, the submission and review processes, award administration and other aspects of the program. The earliest start date is April 2016, not December 2016 as originally indicated in the funding opportunity announcement.
As stated in earlier posts, this first MIRA competition is an experiment and is intentionally limited to a small group of eligible applicants. If this pilot is successful, we plan to issue future funding opportunity announcements covering additional groups of investigators.
UPDATE: The Maximizing Investigators’ Research Award (MIRA) (R35) Web page also includes links to the MIRA webinar and slides, MIRA-specific instructions for listing current and pending support, and a sample NIH biosketch.
We have just issued the first funding opportunity announcement (FOA) in the pilot of our new Maximizing Investigators’ Research Award (MIRA) program. The development of this program was greatly informed by responses to our request for information, which I summarized in a previous Feedback Loop post.
The goal of this FOA is to test the MIRA concept under well-controlled conditions with a small group of investigators. We’re initially targeting established investigators who have received two or more R01-equivalent awards or a single award of $400,000 or more in direct costs from NIGMS in Fiscal Year 2013 or 2014, and who have at least one grant expected to end in Fiscal Year 2016 or 2017. We think that this approach will help these investigators transition smoothly from their current grants to MIRA support. In the future, we plan to issue MIRA FOAs for additional groups of investigators, and if the pilot is successful we will open the program to any investigator working on research questions related to the mission of NIGMS.
If you’re eligible for this FOA and on the fence about applying, consider that MIRA awards:
- Will be for 5 years instead of the current NIGMS average of 4 years,
- Will continue support for other research currently funded by NIGMS without requiring a separate renewal application,
- Will provide flexibility to pursue new ideas and opportunities as they arise,
- Will increase funding stability, and
- Will reduce time spent managing multiple grant awards and writing grant applications.
We’ll post additional information, including answers to frequently asked questions, on the NIGMS MIRA Web page.
NOTE: The FOA lists the earliest award date as December 2016. This is an error. The earliest award date is actually April 2016.
The NIGMS Postdoctoral Research Associate (PRAT) program is now accepting applications for its 50th class of fellows, and I encourage you to pass along this fellowship opportunity to graduate students and early postdoctoral scholars who may be interested in applying. The application deadline is March 17, 2015.
NIGMS PRAT fellows conduct research in scientific areas within the Institute’s mission while in an NIH intramural research program (IRP) laboratory. Before applying to the program, applicants must identify a potential preceptor in the NIH IRP and develop a research proposal.
Applicants must be citizens or permanent residents of the United States who have or will have a doctoral degree (e.g., Ph.D. or M.D.) and no more than 5 years of postdoctoral research experience by the time the 2015 program begins in the fall. Individuals currently in Ph.D. or other doctoral degree-granting programs may apply as long as they anticipate completing the degree requirements before starting the fellowship program.
NIGMS PRAT fellows receive 3 years of stipend support at levels determined by the NIH IRP guidelines and commensurate with experience. Additional benefits include health insurance, a travel allowance and professional development training activities, including a monthly seminar series designed specifically for the fellows. The professional development opportunities provide a rich forum for the exchange of ideas among this diverse group and are often cited by current fellows and alumni as one of the most valuable aspects of the program.
For more information about the NIGMS PRAT program, including details about applying and identifying potential preceptors, please e-mail me.
SAVE THE DATE – The NIGMS PRAT program will host a 50th anniversary scientific symposium highlighting the accomplishments of its alumni, many of whom have achieved senior leadership positions in academia, government and industry. This event will take place on November 6, 2015, on the NIH campus in Bethesda, MD.
You may be interested in these recent funding opportunity announcements:
NIGMS Program of Administrative Supplements for Equipment
Purpose: Request supplemental funds to existing NIGMS-funded R01, R37, P01, and U01 grants for the purchase of single pieces of equipment whose direct costs are between $50,000 and $250,000
Application due date: March 3, 2015
NIGMS contact: Anthony Carter, 301-594-0943
NIH Pathway to Independence Award (Parent K99/R00)
Purpose: Help postdoctoral researchers complete mentored training; transition to independent, tenure-track or equivalent faculty positions; and launch competitive, independent research careers
Application due date: Standard dates apply
Oleg Barski, PPBC, 301-594-3827
Paula Flicker, CBB, 301-594-0828
Michelle Hamlet, GDB, 301-594-0943
Stephen Marcus, BBCB, 301-594-2987
Michael Sesma, TWD, 301-594-3900
Biomedical Big Data Training
NIH Big Data to Knowledge (BD2K) Enhancing Diversity in Biomedical Data Science (R25)
Purpose: Provide undergraduate students from underrepresented groups hands-on exposure to big data research experiences; obtain professional training and skills in big data science
Letter of intent due date: February 19, 2015
Application due date: March 19, 2015
- NIH Big Data to Knowledge (BD2K) Initiative Research Education: Open Educational Resources for Sharing, Annotating and Curating Biomedical Big Data (R25)
Purpose: Develop open educational resources that cover concepts, approaches, relevant use cases and requirements for sharing, annotating and curating biomedical big data
Letter of intent due date: February 17, 2015
Application due date: March 17, 2015
You may be interested in these following NIH Guide announcements:
Request for Information (RFI): Inviting Comments and Suggestions on the Reagent-Related Barriers to Reproducible Research
Purpose: Provide input on reagent-related barriers to reproducible biomedical research
Response date: December 22, 2014
NIH contact: Questions concerning this RFI should be directed to NIHReproducibilityEfforts@nih.gov
Administrative Supplements for Research on Sex/Gender Differences (Admin Supp)
Purpose: Request supplemental funds to existing grants to study the impact of sex/gender differences (or similarities) and/or sex and gender factors in human health and disease processes, including basic, preclinical, clinical and behavioral studies to inform the development and testing of preventative and therapeutic interventions
Application due date: January 12, 2015
NIGMS contact: Regine Douthard, 301-435-1759
Regional Consortia for High Resolution Cryoelectron Microscopy (U24)
Purpose: Provide regional access to state-of-the-art data collection capabilities to cryoelectron microscopy (cryoEM) laboratories; more information is available on the Guidance for Applicants Web page
Letter of intent due date: December 27, 2014
Application due date: January 27, 2015
NIGMS contact: Paula Flicker, 301-594-0828
Change in Application Due Dates for PAR-14-021 "Biomedical Technology Research Resource (P41)"
Purpose: Notice that applications for Biomedical Technology Research Resource grants will no longer be accepted for the September 25 due date; applications will continue to be accepted for the January 25 and May 25 due dates
NIGMS contact: Douglas Sheeley, 301-451-6446
NIGMS supports research in certain clinical areas, primarily those that affect multiple organ systems. To help investigators plan and prepare for clinical research projects, we offer planning grants for clinical trials of high relevance to the NIGMS mission. These planning grants, which we discussed in an earlier Feedback Loop post, can be used to develop management strategies and assemble regulatory documents for large-scale clinical trials.
We recently reissued the funding opportunity announcement for these planning grants. The next application deadline is December 18, with optional letters of intent due by November 18.
If you’re interested in applying for a clinical trial planning grant, we strongly recommend that you consult with the appropriate NIGMS program staff before you apply to determine whether the goal of the proposed trial aligns with the NIGMS mission and scientific priorities.
For more information, see our Clinical Studies and Trials Web page, which includes links to other useful resources like the NIGMS Guidelines for Data and Safety Monitoring in Clinical Trials. In addition, please note that NIH recently revised its definition of “clinical trial” to make a clearer distinction between clinical trials and clinical research studies and to enhance the precision of the clinical trial information NIH collects, tracks and reports.
If you have any questions about NIGMS’ support of clinical trials, please contact me.
NIGMS and the National Institute of Dental and Craniofacial Research are leading the new NIH Common Fund glycoscience program that is focused on the development of accessible and affordable tools and technologies for studying carbohydrates and their functions. The overall objective is to enable researchers in all biomedical fields to dramatically advance understanding of the roles of these complex molecules in health and disease.
The NIH Common Fund recently issued four funding opportunity announcements from this program:
- Data Integration and Analysis Tools: Accessible Resources for Integration and Analysis of Carbohydrate and Glycoconjugate Structural, Analytical, and Interaction Data in the Context of Comparable Gene, Protein, and Lipid Data (R34)
- Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (U01)
- Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (R21)
- Facile Methods and Technologies for Synthesis of Biomedically Relevant Carbohydrates (U01)
The application deadline for each announcement is December 10, with optional letters of intent due by November 10. For more information about the glycoscience program, view the technical assistance Webinar or contact either one of us at firstname.lastname@example.org or email@example.com.
In February, we asked for input on training activities relevant to enhancing data reproducibility, which has become a very serious issue for both basic and clinical research. The responses revealed that there is substantial variation in the training occurring at institutions. One reason is that “best practices” training in skills that influence data reproducibility appears to be largely passed down from generation to generation of scientists working in the laboratory.
To increase the likelihood that researchers generate reproducible, unbiased and properly validated results, NIGMS and nine additional NIH components have issued a funding opportunity announcement to develop, pilot and disseminate training modules to enhance data reproducibility. Appropriate areas for the modules include experimental design, laboratory practices, analysis and reporting of results, and/or the influence of cultural factors such as confirmation bias in hypothesis testing or the scientific rewards system. The modules should be creative, engaging, readily accessible online at no cost and easily incorporated into research training programs for the intended audience, which includes graduate students, postdoctoral fellows and beginning faculty.
The application deadline is November 20, 2014, with letters of intent due by October 20, 2014. Applicants may request up to $150,000 in total costs to cover the entire award period. For more details, read the FAQs.
You may be interested in these recent funding opportunity announcements (FOAs):
Institutional Development Award (IDeA) Program Infrastructure for Clinical and Translational Research (IDeA-CTR) (U54)
Purpose: Develop infrastructure and other resources to conduct clinical and translational research in IDeA-eligible states
Letter of intent due date: 30 days prior to the application due date
Application due dates: October 8, 2014; September 30, 2015; September 30, 2016
NIGMS contact: J. Rafael Gorospe, 301-435-0832
The NIGMS Human Genetic Cell Repository (U42)
Purpose: Maintain the current collection of NIGMS Human Genetic Cell Repository cell cultures and DNA samples; acquire, characterize and expand high-quality cell samples; and distribute cell lines and DNA isolated from them to qualified biomedical researchers
Application due date: October 1, 2014
NIGMS contact: Michael Bender, 301-594-0943