NIH Request for Input: Transformative High-Resolution Cryo-EM

NIH is requesting input from the community on scientific opportunities, critical needs and strategies for realizing the scientific potential of cryo-electron microscopy (cryo-EM). The request for information (RFI) seeks input from researchers, institutions, professional societies and others interested in cryo-EM, including those who have not done any work in the area but have an interest in doing so in the future.

The RFI solicits input on a number of topics, including but not limited to:

  • Cryo-EM needs and capacity.
  • Workforce development and training.
  • Technology development.

RFI responses should be sent to cyro-em@mail.nih.gov by August 8, 2016.

If you have any questions about the RFI, please let me know.

Outcomes Analysis of the NIGMS Institutional Research and Academic Career Development Awards (IRACDA) Program

We recently analyzed the career outcomes of scholars who participated in the NIGMS IRACDA program. A goal of this program is to provide a diverse pool of postdoctoral scholars with research and professional skills needed to be successful in academic careers. The program combines a mentored postdoctoral research experience with an opportunity to develop additional academic and teaching skills, including a teaching practicum at a partner institution that enrolls a substantial number of students from underrepresented groups. Since its inception in 1999, 25 research-intensive institutions have received IRACDA awards, which have supported more than 600 scholars.

Our assessment focused on the 450 alumni who completed their training through November 2014. Important findings include:

  • IRACDA scholars are diverse: 63% are female, and 53% identify as a race/ethnicity other than white, non-Hispanic.
  • Approximately 73% of IRACDA alumni are in academic faculty positions at a range of institutions (see Figure 1).
  • Among the scholars in faculty positions, 35% are at research-intensive institutions, 25% are at primarily undergraduate institutions and the remaining percent are at associate- and master’s degree-granting institutions. In addition, 25% of the IRACDA alumni in academic positions are faculty at a designated minority-serving institution.

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Rochelle Long to Lead Pharmacology, Physiology, and Biological Chemistry Division

Dr. Rochelle LongI’m very pleased to announce the selection of Rochelle Long as director of our Division of Pharmacology, Physiology, and Biological Chemistry (PPBC). Rochelle is a pharmacologist who has played leading roles in fostering research in pharmacogenomics through national and international collaborations.

She established and oversees the trans-NIH Pharmacogenomics Research Network and has catalyzed associated partnerships, such as the Global Alliance for Pharmacogenomics and the Clinical Pharmacogenetics Implementation Consortium.

Rochelle has worked in PPBC since 1990, starting as a program director and rising to become chief of its Pharmacological and Physiological Sciences Branch in 1998. She has served as acting division director since Mike Rogers’ retirement in May 2015.

Rochelle’s plans include building bridges across scientific disciplines, working to strengthen emerging fields and promoting cross-disciplinary research. These are goals across the Institute—they are reflected in our strategic plan—and they’re particularly relevant for a broad-ranging division like PPBC.

Since I’ve had the opportunity to interact with her for several years, I know how skilled Rochelle is at organizing, motivating and generating cohesion among groups of people. These qualities will serve her well as PPBC director and as a member of the NIGMS senior leadership team.

For more about Rochelle, see our news announcement.

Give Input on Strategies for Modernizing Biomedical Graduate Education

We’ve been examining how best to support the modernization of graduate education at the national level to ensure that trainees gain the skills, abilities and knowledge they need to be successful in the biomedical research workforce.

We’re involved in a variety of efforts. For example, we and other NIH institutes and centers provided support for the development of training modules on rigor and reproducibility. We encouraged graduate programs at institutions that receive predoctoral T32 support from us to make their alumni career outcomes publicly available to prospective and current students. We’ve also offered administrative supplements to predoctoral T32 training grants to support innovative approaches in the areas of rigor and reproducibility, career outcomes and graduate education. In April, we held a symposium covering these and other topics in graduate education. Finally, we plan to write a new predoctoral T32 funding announcement.

We’re now soliciting input from the biomedical research community and other interested groups in response to a new request for information (RFI) on strategies for modernizing biomedical graduate education. We’d like to know your thoughts on:

  • Current strengths, weaknesses and challenges in graduate biomedical education.
  • Changes that could enhance graduate education to ensure that scientists of tomorrow have the skills, abilities and knowledge they need to advance biomedical research as efficiently and effectively as possible.
  • Major barriers to achieving these changes and potential strategies to overcome them.
  • Key skills that graduate students should develop in order to become outstanding biomedical scientists and the best approaches for developing those skills.
  • Potential approaches to modernizing graduate education through the existing NIGMS institutional predoctoral training grants.
  • Anything else you feel is important for us to consider.

Responses can be submitted via an online form Exit icon and can be anonymous. They can also be emailed to modernPhD@mail.nih.gov. The due date for responses is August 5, 2016.

Wanted: Scientific Review Officer

We’re recruiting a scientific review officer to manage the peer review of grant applications in a wide range of research, training, capacity-building and other NIGMS programmatic areas. We seek candidates with broad scientific backgrounds as well as expertise in one or more of these (or related) biomedical research fields: cell and molecular biology, genetics, developmental biology, pharmacology, physiology, biological chemistry and biophysics. We especially encourage applications from candidates who have demonstrated a commitment to mentoring, particularly of individuals from groups that are underrepresented in biomedical research, and/or have experience with capacity-building programs at institutions in states that have historically received low levels of NIH funding.

There are two vacancy announcements: one for candidates with current or former federal employment status Exit icon and one for candidates without such status Exit icon. Both vacancies close on June 13, 2016. Please see the NIH HSA website for position requirements and application procedures. For more information about the position, contact David Wittenberg at 301-451-1828.

Sharing Our Passion for Science

NIGMS Director Dr. Jon R. Lorsch explains a protein letter computer activity to a young participant at the USA Science and Engineering FestivalA few weeks ago, 23 NIGMS volunteers and I spent an amazing day with thousands of highly engaged kids, their parents and other science enthusiasts of all ages at the Washington, DC, Convention Center. We were participating in the USA Science & Engineering Festival, the largest STEM event in the nation.

The NIGMS booth was a big hit! Our theme was Cell-e-bration of Science,
with activities that included spelling names with protein letters and a
“selfie station” with science-related props.Festival participants at the NIGMS selfie station holding science themed props in front of a colorful backdrop of a cell

Getting young people interested in science is essential to building a vibrant and innovative research enterprise. The Science & Engineering Festival, with more than 365,000 participants, gave us a chance to share our passion for science with thousands of young people. Hopefully, some of the kids we met are now thinking about careers as scientists.

NIGMS staff volunteer demonstrating how the protein letter computer activity worksI encourage you to share your own enthusiasm for science with young people whenever you have the opportunity. Whether you judge a science fair, speak at a career day or have students visit your lab, you put a human face on science and help students see it as an exciting, fulfilling and worthy career choice.

 

Long-Time Scientific Review Chief Helen Sunshine Retires

Dr. Helen SunshineHelen Sunshine, who led the NIGMS Office of Scientific Review (OSR) for the last 27 years, retired in April. Throughout her career, she worked tirelessly to uphold the highest standards of peer review.

Helen earned a Ph.D. in chemistry at Columbia University and joined the NIH intramural program in 1976, working first as a postdoctoral fellow and then as a senior research scientist in the Laboratory of Chemical Physics, headed by William Eaton.

In 1981, Helen became a scientific review officer (SRO) in OSR and was appointed by then-NIGMS Director Ruth L. Kirschstein to be its chief in 1989. During her career in OSR, she oversaw the review of many hundreds of applications each year representing every scientific area within the NIGMS mission.

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Small Business Opportunity to Develop Cell Line Identification Tools

Misidentified and contaminated cell lines are believed to be a significant cause of irreproducible and non-generalizable research results. Although this issue has been widely discussed, including on this blog, surveys have shown that many researchers find the costs, time and effort of cell line authentication to be barriers to using it as a routine quality-control measure. There’s a new trans-NIH Small Business Innovation Research (SBIR) initiative that aims to reduce these barriers and make cell line authentication affordable and routine.

Along with other parts of NIH, we’re participating in a funding opportunity announcement (FOA) to support SBIR projects focused on developing novel, reliable, rapid and cost-effective tools to assist researchers in confirming the identity and/or sex of the cells that they use in their work. The FOA will also support the development of tools for cases in which there are currently no good methods of identification, such as distinguishing between cells derived from inbred mouse lines. We encourage applications from all eligible organizations. Standard application due dates apply.

If you’re interested in applying and would like more information, you can email me, my NIGMS colleague Zhongzhen Nie or other NIH program staff listed in the FOA. We look forward to receiving your best ideas for developing and commercializing new cell line identification tools.

Distribution of NIGMS R01 Award Sizes

We have published median and mean direct cost award amounts for R01 grants, but these statistical aggregates can mask variations present in our grant portfolio. In this analysis, we illuminate two major differences in R01 award size distributions: those between single-principal investigator (PI) and multiple-PI (MPI) grants and those between new and competing renewal grants. It is worth noting that the numbers are per award values rather than the total NIGMS support provided to investigators and that award size can also be influenced by NIH-wide policies and NIGMS-specific policies that promote the consideration of multiple factors in making funding decisions.

The first major distinction in NIGMS R01s exists between single-PI and MPI awards. NIH has allowed applications that identify more than one PI since Fiscal Year 2007. Many MPI applications request, and receive, larger amounts of funding than do typical single-PI applications. As shown in Figure 1, single-PI awards have a size peak in the range of $175,000-200,000 in direct costs (funds typically directly associated with the research project rather than overhead costs), while MPI awards tend to have larger budgets and a broader size distribution. MPI awards are, on average, approximately 25% larger for each additional PI (data not shown).

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Meeting Showcases Innovations in Biomedical Graduate Education

NIGMS Symposium on Catalyzing the Modernization of Graduate Education

NIGMS Director Jon Lorsch addresses attendees at the symposium, which is available on videocast.

On April 11, more than 150 people from across the country (plus many via videocast) participated in the NIGMS Symposium on Catalyzing the Modernization of Graduate Education. The goals of the meeting were to convene stakeholders to continue the momentum for positive change within the biomedical graduate education community and to showcase innovative experiments and approaches in Ph.D. training.

The morning session featured presentations highlighting the training expectations of graduate students, institutional approaches to reshaping graduate education programs and attributes employers look for when hiring early career scientists. These talks converged on the theme of ensuring that graduate education equips Ph.D. students with the scientific and professional skills they need to be successful in their careers.

After a presentation focusing on assessing the effectiveness of educational innovations, the speakers in the afternoon session described a variety of experiments in graduate education that are currently under way in various settings. The nine innovations featured in this session were augmented by an additional 32 posters presented during the lunch period.

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