Category: Meetings/Events

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Upcoming Advisory Council Meeting Includes Videocast and Public Comment Period Opportunities

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The National Advisory General Medical Sciences Council will have its fall meeting on September 19-20. For the session open to the public on the second day, we will be trying something new: a videocast. If you’re interested in watching the presentations and subsequent discussions—and learning more about what happens during advisory council meetings—tune in at http://videocast.nih.gov. The videocast will also be archived for a limited time. If enough people watch the meeting live or later, making the experiment successful, we will continue to videocast the open session of future advisory council meetings.

Previously, the Feedback Loop posted a description of advisory council roles. Council members provide the second level of peer review of grant applications, assess the merits of appeals of study section reviews and provide ideas and guidance on scientific and training priorities.

We have just posted the open session agenda, which includes a presentation by Council member and Yale University chemistry professor and chair Scott Miller on recent discoveries at the chemistry-biology interface; a presentation by NIH Principal Deputy Director Larry Tabak on data reproducibility in biomedical research; and another new feature of the meeting: a period reserved for public comment.

Before I started at NIGMS, I was able to attend the open session of the May Council meeting, where I heard very exciting presentations about recent developments in cryo-electron microscopy and pharmacogenomics, plus lively discussions about training and workforce development issues. Although I have only been to this one meeting so far, based on what I heard at it, I recommend that you try to catch some of the September meeting—I think you’ll find it interesting and informative.

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Chemical Biology Career Workshop Builds Model for Similar Efforts

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CBI Career Development Conference Program CoverAn action recommended in our strategic plan for biomedical and behavioral research training and by a working group of the Advisory Committee to the Director, NIH, is providing graduate students with a greater awareness of their career options. An inaugural career development conference that we co-sponsored and that was recently highlighted in a Chemical & Engineering News article Link to external web site may lead to the development of a sustainable workshop model to inform graduate students about and help them prepare for a range of scientific careers.

Organized by the directors of chemistry-biology interface graduate training programs at 10 Midwestern institutions, the 3-day event took place in June on the University of Illinois at Urbana-Champaign campus. It brought together nearly 100 graduate students and 30 career mentors with jobs in academia, government and the private sector, including in nontraditional areas such as consulting, patent law and communicating science to the public.

A significant portion of the meeting consisted of structured discussion and presentations organized around different job opportunities. The meeting also included activities that let students improve their communication skills by explaining their research clearly and concisely to various audiences. Other career sessions focused on entrepreneurship and acquiring a postdoctoral position.

Early in the group discussions, students considering careers outside academia shared their concerns about the job market and about whether their graduate research training might potentially narrow their employment opportunities.  By the end of the meeting, however, most had the sense that their graduate training would actually open up new opportunities.  The group discussions also enhanced the mentors’ knowledge of various career paths and raised their awareness of the students’ career development needs.

A formal evaluation of the meeting’s usefulness and effectiveness is under way, and the organizers are experimenting with a variety of novel approaches to ensure sustainability for the conference by rotating venues, sharing organizational responsibilities and developing consistent sponsorships.

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Meeting to Highlight NIGMS-Funded Systems Biology Program

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National Centers for Systems Biology Portal - Find updates, news stories, training opportunities and moreFor 10 years, our National Centers for Systems Biology (NCSB) program has enabled pioneering research, research training, education and outreach programs focused on systems-level inquiries of biomedical phenomena within the NIGMS mission.

Currently, the program funds 15 centers that are focused on molecular and cellular biology, genetics, pharmacology and physiology. The centers have advanced research in these scientific areas and have significantly contributed to the development of systems biology courses, graduate programs and departments at institutions across the nation, supporting and further building research teams that integrate expertise across traditional disciplinary boundaries.

To mark the program’s anniversary, we are hosting a special annual centers meeting to inform the broader scientific community about the status and achievements of the program. In addition to presentations highlighting each center’s activities, the agenda includes a plenary talk by Arthur Lander of the University of California, Irvine, titled “Lighting the Way: Ten Years of National Centers for Systems Biology,” and presentations by young scientists whose careers have been impacted by the program.

The meeting will be held on July 11-12 in the Natcher Conference Center on the NIH campus. You can now register to attend and see who is participating (no longer available).

Here are a few examples of how the research being conducted by the NIGMS-funded systems biology centers is advancing our knowledge in a broad range of scientific areas:

  • The Virtual Physiological Rat Project  Link to external web site at the Medical College of Wisconsin used data analysis and computational modeling to show that arterial stiffening alone best explains the development of hypertension in aging individuals; the methodology can serve as a model for studying the basis of other diseases.
  • The Center for Systems and Synthetic Biology at the University of California, San Francisco, has created minimal circuits that can reprogram the self-organization of structures within the cell, offering a potential method for engineering cells to carry out specific therapeutic functions.
  • Using dynamical modeling, the San Diego Center for Systems Biology at the University of California, San Diego, has helped explain how quantitative differences in epigenetic steady states may result in qualitatively different cell-type-specific control of signaling.
  • The Center for Complex Biological Systems at the University of California, Irvine, has provided novel insights into the strategies underlying robust pattern formation in biological systems.
  • The Center for Modular Biology at Harvard University has explored whether networks of interacting components, or modules, are pervasive building blocks in biological systems, and how the existence of these building blocks restrains or enhances the generation of diversity.
  • The Center for Systems Biology  Link to external web site at the Institute for Systems Biology is seeking out how dynamic molecular networks of cells process inputs from their environment to mount appropriate responses, such as metabolic, morphological and phenotypic changes.
  • The Center for Genome Dynamics  Link to external web site at the Jackson Laboratory has developed and commercialized two highly sought-after genotyping platforms that are useful in mouse research.

For more highlights, including a recent award from Science magazine for an online computational biology course from the Center for Genome Dynamics, see the NCSB news page. An array of databases, software and other resources, including training materials, developed by the centers are available for use through the NCSB portal (no longer available).

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Research on Women in Biomedical Careers

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A group of NIH grantees convened last November to present and discuss their studies on causal factors and possible interventions affecting the representation of women in biomedical and behavioral research and engineering. Their work is funded through a trans-NIH initiative spearheaded by NIGMS and the Office of Research on Women’s Health. Through this effort, NIH is gathering evidence that will help guide future plans and actions in this arena.

Here are several key areas of focus that are emerging from the research:

  • Bias is powerful and often unconscious, but it can be measured, and it can be altered.
  • Mentor networks are often more effective than mentor pairs.
  • Workplace culture affects career satisfaction and performance, and aspects of culture can be measured and changed.
  • Institutional flexibility policies are typically under-recognized and under-used, in part due to ingrained academic culture and lack of leadership buy-in.

For more on the workshop, read the just-posted summary.

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Reflecting on 10 Years of Modeling Disease Spread

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The NIGMS Models of Infectious Disease Agent Study (MIDAS) is a collaborative network of about 100 scientists who use computational, statistical and mathematical models to understand infectious disease dynamics.

As we mark the program’s 10th anniversary, we invite you to join us for a symposium titled “Modeling for Science and Policy” on September 23 from 9 a.m. to 4 p.m. EDT at the Lipsett Auditorium on the NIH campus. You can also watch the symposium remotely (live or later) via the NIH Videocast Web site. The program will feature short talks by MIDAS researchers on modeling for scientific understanding, for health policy decision making and for preparedness planning. We’ll post more details about the symposium when they’re available.

We also welcome scientists to apply for grants to become part of the network. We just released funding opportunity announcements for MIDAS centers of excellence (U54), an information technology resource (U24) and research projects (U01).

Since its inception, MIDAS has pioneered the use of computational and mathematical models to prepare for, detect and respond to infectious disease threats. In addition to doing basic quantitative and computational biology, MIDAS works closely with local, state and federal public health agencies to facilitate the use of modeling in decision making.

Here are just a few examples of MIDAS activities:

  • Working with the Institute of Medicine and the National Association of County and City Health Officers, MIDAS held a workshop at the 2013 Public Health Preparedness Summit to demonstrate how modeling can be used by local public health officials to inform policy decisions.
  • The University of Pittsburgh center has developed a software program called FRED that uses high-performance computing to create virtual outbreaks and deliver the results to a smartphone. The approach could enable public health officials to employ modeling tools even when they aren’t at their computers.
  • The Harvard School of Public Health center is developing models for the emergence of drug resistance in influenza, tuberculosis and other diseases to study the implications for clinical decision making.
  • The University of Chicago project uses large-scale computational modeling to explore the dynamics of MRSA among incarcerated and other communities on the south side of Chicago.
  • The University of Washington project has examined the impact of vaccine policies and usage on halting the spread of cholera in Haiti.
  • The Virginia Bioinformatics Institute project is developing a computer activity to teach high school students how epidemiologists study outbreaks and use mathematics and computation to help make public health decisions about vaccine distribution and school closures, for example.
  • The MIDAS information technology resource has developed detailed virtual human populations for many countries, including the United States, Mexico, Thailand, China and Argentina. These populations allow investigators to simulate social networks, transmission dynamics and the impact of behavior and policies on disease spread.

The network’s models, software and other resources, including information about historical epidemics, are available through the MIDAS portal. If you’re interested in modeling and/or infectious diseases, I invite you to explore this site, and I welcome your questions.

CORRECTION: The symposium will take place in the Lister Hill Center Auditorium on the NIH campus.

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Networking Theme for 2013 Training, Workforce Development, and Diversity Program Directors’ Meeting

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TWD Program Directors' MeetingA goal of our Division of Training, Workforce Development, and Diversity (TWD) is to create a community of trainers and educators dedicated to developing a well-prepared, diverse biomedical research workforce.

Toward that end, the focus of this year’s TWD Program Directors’ Meeting (link no longer available) is on networking. The meeting, to be held on June 12-14 in Chicago, will address the value of sustained networking among the grantees, students and other communities served by these programs. The meeting will enable program directors to learn more about other TWD programs; establish connections with potential new partners, especially regional “neighbors”; and collectively address the Institute’s research training objectives.

Plenary sessions and keynote talks will cover the diversity of the U.S. research workforce, STEM training in the context of NIH-funded biomedical and behavioral research, and innovative approaches for evaluating and assessing our training programs. NIGMS and NIH leaders will give overviews of the Institute’s training strategic plan and the implementation of the report from the Diversity in the Biomedical Research Workforce Working Group of the Advisory Committee to the Director, NIH.

The meeting is primarily intended for program directors and associate deans (or the equivalent) at institutions with these TWD student and predoctoral training programs: Bridges to the Baccalaureate, Bridges to the Doctorate, IMSD, IRACDA, MARC T36, MARC U-STAR, RISE, PREP, NIGMS T32 predoctoral programs and IDeA INBRE.

Online registration is open now at www.TWDNIGMS.org (no longer available) and closes May 10, 2013.

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Improving Homology Modeling

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While the Protein Data Bank includes nearly 88,000 protein structures that were determined experimentally, there are millions more proteins whose structures are unknown. Comparative or homology modeling offers a powerful approach for leveraging solved structures to reveal important biological details about the others.

Two efforts, both funded through the Protein Structure Initiative, are evaluating the current state of our ability to model protein structures and complexes and seeking ways to further advance the accuracy and usefulness of homology modeling.

GPCR Dock 2013

The NIGMS-funded GPCR Network is hosting its third round of the GPCR Docking and Modeling Assessment, GPCR Dock 2013. This assessment of homology modeling and docking methods is focused specifically on G protein-coupled receptors (GPCRs), seven-transmembrane proteins that help transmit essential signals from a wide range of hormones and neurotransmitters in the body and that are a major target of existing drugs. Participants will submit prediction models for four target GPCR-ligand complexes recently determined by GPCR Network investigators and yet to be published. An analysis of the results will be available a few months after the March 3 submission deadline. To participate, register by February 1. For more information, contact the organizers.

Technology Development for Protein Modeling Funding Opportunity

As I stated last month, we have reissued the Technology Development for Protein Modeling (R01) funding opportunity announcement. It encourages grant applications from institutions that propose to develop novel technologies that will significantly improve the accuracy of comparative modeling methods for protein structure prediction. Applicants should focus on one or both of these goals:

  • Near-crystal-structure quality for close homologs of known structures, and/or
  • High-accuracy models for remote homologs of known structures.
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Web Chat Stimulates Student Interest in Cells, Research Careers

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Joe Gindhart, Sirisha Kumpatla, Judith Greenberg, Jen Villani, Ward Smith, John Laffan, Shari Tutt and Brian Pike (pictured left to right) were among many NIGMS staff members who participated in Cell Day. Courtesy of Peter Rice.Last Friday, we hosted Cell Day–an extremely exciting online interactive chat about the cell. During the event, many members of our scientific staff, including our Acting Director, Judith Greenberg, fielded more than 140 questions from mostly 5th through 12th grade students and teachers across the country.

We anticipated some of the questions we’d be asked, but many surprised and impressed us. Some questions got us thinking about how we know what we know and let us share why we became scientists. Here are a few examples:

  • Do my cells think?
  • Which living organism has the most cells?
  • Why have plants not evolved to be black in color in order to maximize light absorption?
  • What inspired you to take an interest in biology and its beautiful diversity?

Read the transcript to view more questions and our answers.

While Cell Day was developed as an NIGMS 50th anniversary activity, we enjoyed it so much that we plan to do it again next year as part of our continued commitment to science education.

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Watch Our 50th Anniversary Scientific Symposium Online

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DeWitt Stetten, Jr. 50th Anniversary Symposium poster.

We’re looking forward to a very special event this week—a symposium on the NIH campus marking our 50th anniversary. If you can’t join us in person, you can watch the talks online.

The event is on Wednesday, October 17, from 1:00 to 4:00 p.m. Eastern time. NIH Director Francis Collins will lead things off by sharing his perspective on the Institute and the research it funds. Next will be talks by three NIGMS grantees—Carlos Bustamante, Kathy Giacomini and Tim Mitchison—who reflect the range of our support as well as the theme of our anniversary: “investigate, innovate, inspire.”

You can watch the event live or later.