NIGMS is actively involved in NIH-wide efforts to enhance rigor and reproducibility in research. As part of our work on this issue, we will co-host a trans-NIH workshop on September 28-29, 2015, to examine current quality-control challenges in cell culture research and identify opportunities for expanding its capabilities and applications. The meeting will be videocast and archived on the NIH Videocasting site.
The workshop agenda includes panel discussions led by researchers from academia and industry on cell line identification, genetic and phenotypic characterization of cells, heterogeneity in populations of cells, reagents, and research and reporting standards. The meeting will also cover new approaches to understanding the characteristics and behaviors of cultured cells and technologies for enhancing their usefulness in research.
Beginning at this month’s meeting of the National Advisory General Medical Sciences Council, some of the ad hoc Council members will be early career investigators. We expect to benefit from their ideas and insights, and we also hope that they will get a better understanding of the workings of Council and share what they learn with peers.
As most of you know, the Advisory Council provides the second level of review required before any grant can be funded. The Council also advises the Institute on policy and scientific matters. Regular Council members are appointed by the HHS Secretary, but for most meetings, we invite ad hoc consultants to expand the Council’s breadth of expertise. Both regular and ad hoc members are typically at fairly senior career levels—often full professors or deans. We think there is value in inviting one or two early career investigators to each Council meeting as ad hocs to provide a greater diversity of views.
We’ve identified a perfect pool to draw from: the Early Career Reviewers who have participated in a study section for NIH’s Center for Scientific Review. If you are interested in applying to this CSR program, see How to Apply.
UPDATE: Due to technical difficulties, the MIRA webinar was not recorded. We have posted the slides on the MIRA Web page, where we’ll also post a summary of the webinar questions and answers.
NIGMS Director Jon Lorsch and I will field questions about the recently announced Maximizing Investigators’ Research Award (MIRA) for New and Early Stage Investigators (R35) during a webinar on Tuesday, June 30, from 1-2 p.m. EDT. Participants will be able to submit questions using the chat feature. We’ll post the archived webinar and slides on the MIRA Web page.
The most common questions we’re getting about the new MIRA funding opportunity announcement (FOA) have concerned eligibility, so we created a new flowchart to help determine this. Another common question has related to research areas appropriate for support by a MIRA. These and other topics are covered in our answers to frequently asked questions about the second MIRA FOA.
If you have colleagues who may be eligible to apply but may not know about the FOA or may have questions about it, please share this post with them.
As with the first MIRA FOA, this competition is an experiment and is intentionally limited to a small group of eligible applicants. If the pilot is successful, we plan to issue future FOAs covering additional groups of investigators.
For more information about the MIRA program, e-mail me or call me at 301-594-0828.
PRAT Symposium Speakers
Steven Paul, Weill Cornell
Jacqueline Crawley, UCSD
Richard Weinshilboum, Mayo Clinic
Katherine Roche, NIH
James Stevens, Eli Lilly
Jennifer Elisseeff, Johns Hopkins
Jennifer Lippincott-Schwartz, NIH
Elizabeth Grice, U Penn
Robert Ruffolo, Jr., Wyeth (retired)
Henry Bourne, USCF
In the years since the first cohort of postdoctoral fellows entered the NIGMS Pharmacology Research Associate (PRAT) program in 1965, the program’s alumni have become leaders in pharmacology, neuroscience, cell biology and related fields across multiple career sectors, including academia, government and industry. On November 6, we’ll mark the accomplishments of the more than 400 PRAT alumni in a full-day scientific symposium on the NIH campus in Bethesda, MD.
The symposium will feature presentations by 10 alumni spanning the duration of the program and is free and open to the public, although we encourage you to register to attend. If you can’t be there in person, you can watch the event live or later. If you have comments, anecdotes, historical data or photos from the PRAT program, please let us know by writing a note in the comments box on the meeting registration site or by sending me an e-mail message.
NIGMS Director Jon Lorsch and I will field your questions about the recently announced Maximizing Investigators’ Research Award (MIRA) (R35) during a webinar on Thursday, Feb. 19, from 2-3 p.m. EST. You’ll be able to access the webinar at https://webmeeting.nih.gov/nigmsmira/. During the event, you can submit questions by calling 301-451-4301 or e-mailing me. You also can send questions to me ahead of time.
Since announcing this new funding opportunity, we’ve received many inquiries. The most common questions have concerned eligibility, so we created a flowchart to help you determine this. Our MIRA Answers to Frequently Asked Questions offer additional details about eligibility, the submission and review processes, award administration and other aspects of the program. The earliest start date is April 2016, not December 2016 as originally indicated in the funding opportunity announcement.
As stated in earlier posts, this first MIRA competition is an experiment and is intentionally limited to a small group of eligible applicants. If this pilot is successful, we plan to issue future funding opportunity announcements covering additional groups of investigators.
UPDATE: The Maximizing Investigators’ Research Award (MIRA) (R35) Web page also includes links to the MIRA webinar and slides, MIRA-specific instructions for listing current and pending support, and a sample NIH biosketch.
The open session of the next meeting of the National Advisory General Medical Sciences Council will be on Friday, January 23. It will begin at 8:30 a.m. with remarks by NIGMS Director Jon Lorsch and continue with reports on a variety of Institute activities and, as usual, a period for public comments.
You can attend the meeting in person or watch it remotely live or later via NIH Videocast.
Our next National Advisory General Medical Sciences Council meeting is September 18-19, 2014. Although the first day is a closed session, Friday’s portion of the meeting is open to the public. You can watch the open session online.
Friday’s presentations begin at 8:30 a.m. with opening remarks by NIGMS Director Jon Lorsch. In addition, the agenda includes presentations by staff on a variety of Institute activities as well as a concept clearance for the pilot to support NIGMS investigators’ overall research programs.
You’re also welcome to attend the meeting in person and make comments during the public comment period.
If you can’t view the meeting live, you can watch it later in the videocast archive.
This year is the 50th anniversary of the NIGMS Medical Scientist Training Program (MSTP), which supports research training leading to the combined M.D.-Ph.D. (or other dual) degree. Starting with only three institutions and a handful of supported students, the program has grown to 45 institutions and more than 900 trainees per year.
We’re marking this milestone year with a symposium on Thursday, July 17, from 8:00 a.m.-12:00 p.m. on the NIH campus in Bethesda, MD. The event will feature remarks by NIH Director Francis Collins and Association of American Medical Colleges President and CEO Darrell Kirch as well as talks by seven current and former MSTP trainees.
Although the symposium is free, we would like participants to register to attend. If you can’t join us in person, you can watch the event live online.
Plans for a scholarly article highlighting the history of the MSTP are under way. If you have comments, anecdotes, historical data, photos or other relevant images, please let us know by writing a note in the comments box on the meeting registration site or by sending me an e-mail message.
The latest update brings the total number of PDB entries to 100,147.
The Protein Data Bank (PDB) just passed a major threshold—the release of its 100,000th entry. This free online repository of experimentally determined protein and nucleic acid structures, which NIGMS and other parts of NIH have helped fund since 1978, facilitates atomic-level insight into protein structure and function. PDB is widely used by the scientific community to study basic biological processes like transcription, translation, enzymology, bioenergetics and metabolism and also for more medically oriented investigations into disease mechanisms and drug design.
In addition to scientists, students and educators use the digital resource for their own explorations of protein structure, function and interactions as well as to gain greater knowledge about biology.
Approximately 260,000 visitors access PDB each month. Scientists around the world currently deposit about 200 structures per week, which PDB staff review, annotate and augment with links to other relevant biological data. To meet the challenges posed by large structures, complex chemistry and use of multiple experimental methods, the repository recently launched a software tool for structure deposition and annotation .
If you aren’t already a PDB user, I encourage you to check out its resources to see if they could help advance your research.