Category: Resources

Funding Opportunity: NIGMS National and Regional Resources

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UPDATE: The slides [PDF, 296KB] from the National and Regional Resources Webinar have been posted.

Research resources provide access to technologies, methods, and expertise that are not generally available to individual laboratories. Large-scale research resources can significantly broaden access to cutting-edge technologies and can achieve economies of scale not possible for facilities serving individual institutions.

We have just published a new funding opportunity announcement (FOA) to support national and regional (multistate) resources for biomedical research that will provide access to state-of-the-art facilities, equipment, technologies, research tools, and software to many users. We expect the impact of these resources and the number of users to be on a similar scale to what is achieved by synchrotron beamlines and cryo-electron microscopy centers.

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Administrative Supplements for NIGMS Predoctoral T32 Grants to Develop Curricular and Training Activities

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To continue our efforts to catalyze the modernization of biomedical graduate education, we invite eligible NIGMS-funded T32 predoctoral training programs to submit administrative supplement requests (NOT-GM-19-015) to develop new curricular and training activities that enhance the program’s ability to: 1) provide graduate trainees with a strong foundation in research design and methods in areas related to conducting rigorous and transparent research to enhance reproducibility; 2) prepare students for diverse careers in the biomedical research workforce; 3) develop the knowledge and skills of trainees to enhance laboratory safety; and 4) develop the technical, operational, and professional skills of predoctoral biomedical researchers.

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Supplements for MIRAs: Clarifying the Policy

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UPDATE: The chart below was updated in June 2020. Revisions to the R35 program are allowable to address special research priorities, e.g. COVID-19.

Since supplemental grant funding comes in a variety of flavors, with different purposes, it’s not surprising that there’s confusion about which kinds of supplements MIRA grantees may apply for and which they may not. Here’s a quick run-down.

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Administrative Supplements to Add Research on Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias

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NIGMS, along with other NIH Institutes and Centers, has partnered with the National Institute on Aging to grow the community of scientists actively engaged in research focused on Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD). Details of this year’s AD/ADRD supplement program are provided in NIA’s Notice NOT-AG-18-008. If your research, research training, or research capacity-building grant is not currently focused on AD/ADRD and you have an inspiring new idea of potential value to the field that is within the scope of the funded Specific Aims of your current award, please consider this opportunity.

Research related to AD/ADRD might fall within the scope of an already-funded NIGMS award originally focused on, for example, an enzyme, transporter, or metabolic pathway being studied for its basic biological or physiological role (or a non-AD/ADRD-related medical condition) if you have recognized an exciting new implication for AD-type pathologies or their treatment. Funded projects developing analytical methods, tools or technologies, drug molecules, or drug delivery systems not previously intended for application to AD/ADRD might now appear to have potential in this area. Potential applicants are strongly encouraged to contact their program director to discuss their ideas for AD/ADRD research and how those relate to the Specific Aims currently funded. Decisions about scope are strictly the purview of NIH. Center and Resource grants that allow non-specified pilot projects should consider adding AD/ADRD projects if interest and expertise exist.
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Administrative Supplements for NIGMS Predoctoral T32 Grants to Develop Curricular and Training Activities

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To continue our efforts to catalyze the modernization of biomedical graduate education, we invite eligible NIGMS-funded T32 predoctoral training programs to submit administrative supplement requests to develop new curricular and training activities to enhance the program’s ability to: 1) provide graduate trainees with a strong foundation in research design and methods in areas related to conducting rigorous and transparent research to enhance reproducibility (PA-18-756); 2) prepare students for diverse careers in the biomedical research workforce (PA-18-757); 3) develop the knowledge and skills of trainees to enhance laboratory safety (PA-18-758); and 4) develop the technical, operational, and professional skills of predoctoral biomedical researchers (PA-18-759).

Grantees should consider the following before applying:

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NIGMS Administrative Supplements for Equipment

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UPDATE: For additional information, see the Notice of Availability of Administrative Supplements for Equipment Purchases for NIGMS Awardees, NOT-GM-18-022. Applications are due May 31.

NIGMS is offering administrative supplements of between $50,000 and $250,000 for the well-justified purchase of single pieces of equipment. In past years, we issued separate funding announcements (PA-15-089 and PA-16-125) for this purpose. This year, however, we will accept requests for equipment supplements from Principal Investigators (PIs) who hold NIGMS R01, R35, R37, or R15 awards under PA-18-591, Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional).

Eligible investigators are strongly encouraged to discuss potential requests with their program directors before submitting applications. Two or more NIGMS grantees at the same institution may submit separate but cross-referenced requests, where the funds requested reflect the actual proportion of the time that the shared equipment would be used by each PI. However, under no circumstances may a joint request exceed $400,000 in direct costs. The requested supplemental budget cannot exceed the total year direct cost amount of the parent award. PIs may not request future year funds. NIGMS strongly encourages investigators to seek matching funds from their institutions or elsewhere, and to ensure that follow-up expenses (such as maintenance contracts) will be covered from other available funds. Institutional contributions and commitment will be factored into funding decisions.

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Funding Opportunity for Development of Training Modules to Enhance the Rigor and Reproducibility of Biomedical Research

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It’s crucial that the results of NIH-supported biomedical research are reproducible, unbiased, and properly validated. Establishment and use of rigorous and reproducible approaches require appropriate and sustained training of researchers and students. In 2014, we announced a funding opportunity to develop, pilot, and disseminate training modules to enhance data reproducibility. The products of these grants are posted on the NIGMS website as they become available, together with other relevant training modules about conducting rigorous and reproducible research.

We’ve just reissued a funding opportunity announcement (FOA) to support the development of additional training modules in three areas that build upon and extend those targeted through the previous FOA. The three new areas of emphasis are: 1) How scientific culture, organization, and incentives influence the rigor and reproducibility of biomedical research; 2) Good laboratory practices and record keeping; 3) Advanced experimental design and analysis.

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