A few weeks ago, 23 NIGMS volunteers and I spent an amazing day with thousands of highly engaged kids, their parents and other science enthusiasts of all ages at the Washington, DC, Convention Center. We were participating in the USA Science & Engineering Festival, the largest STEM event in the nation.
The NIGMS booth was a big hit! Our theme was Cell-e-bration of Science,
with activities that included spelling names with protein letters and a
“selfie station” with science-related props.
Getting young people interested in science is essential to building a vibrant and innovative research enterprise. The Science & Engineering Festival, with more than 365,000 participants, gave us a chance to share our passion for science with thousands of young people. Hopefully, some of the kids we met are now thinking about careers as scientists.
I encourage you to share your own enthusiasm for science with young people whenever you have the opportunity. Whether you judge a science fair, speak at a career day or have students visit your lab, you put a human face on science and help students see it as an exciting, fulfilling and worthy career choice.
Helen Sunshine, who led the NIGMS Office of Scientific Review (OSR) for the last 27 years, retired in April. Throughout her career, she worked tirelessly to uphold the highest standards of peer review.
Helen earned a Ph.D. in chemistry at Columbia University and joined the NIH intramural program in 1976, working first as a postdoctoral fellow and then as a senior research scientist in the Laboratory of Chemical Physics, headed by William Eaton.
In 1981, Helen became a scientific review officer (SRO) in OSR and was appointed by then-NIGMS Director Ruth L. Kirschstein to be its chief in 1989. During her career in OSR, she oversaw the review of many hundreds of applications each year representing every scientific area within the NIGMS mission.
Continue reading “Long-Time Scientific Review Chief Helen Sunshine Retires”
Mike Rogers, who has directed the NIGMS Division of Pharmacology, Physiology, and Biological Chemistry for the past 22 years, retired today. Throughout his NIH career, Mike has been a champion for chemistry and its important role in biomedical research.
Before joining NIGMS 26 years ago, Mike worked for more than a decade in what is now the Center for Scientific Review, where he oversaw the Bioorganic and Natural Products study section.
Between these two positions, Mike completed a detail assignment on Capitol Hill working for Senator Ted Kennedy’s Health, Education, Labor and Pensions Committee, an experience that he says allowed him to see NIH from a different perspective.
Throughout his time at NIGMS, Mike has sought to build scientific bridges. He created the chemistry-biology interface predoctoral training program, which aims to cross-train students in both disciplines. He was instrumental in developing the large-scale collaborative project awards program that “glued” together scientists with diverse expertise to tackle big, unanswered questions in biology. More recently, he forged a link between two fields to help form the new field of quantitative and systems pharmacology. Along the way, he mentored and encouraged others to develop major NIGMS and trans-NIH initiatives, such as those in glycoscience, pharmacogenomics and synthetic organic chemistry.
Continue reading “Division Director Mike Rogers Retires”
Our interest in quantitative and systems pharmacology (QSP) began in 2007 as a question about why we were seeing so little integration between two fields we fund: systems biology and pharmacology. We recognized that connecting them could improve our understanding of drug action and speed drug discovery and development while also increasing our scientific understanding of biology.
To examine the potential of quantitative, systems approaches to pharmacology research, we sponsored two workshops in this area, one in 2008 and the other in 2010. After the second meeting, a committee of external scientists who were also workshop participants began drafting a white paper to assess the state of the science and enumerate the opportunities, needs and challenges for QSP as an emerging discipline.
The committee recently issued the white paper.
The paper makes the case that this post-genomic era is the right time to develop and employ quantitative, systems approaches to understand drug action more predictively, and that the need and excitement for doing so is building. Already we are starting to see evidence of this field emerging—the University of California, San Francisco, has started a Center for Quantitative Pharmacology , and Harvard Medical School just announced an Initiative in Systems Pharmacology . Also, the American Association of Pharmaceutical Sciences annual meeting this month will include a session called, “Achieving the Quantitative and Systems Pharmacology Vision.”
The overall recommendation of the workshop committee is for pharmacology to move beyond characterizing drug/target interactions to a holistic quantitative understanding of drug action across many levels—from drug-receptor interactions to drug response in humans. As stated in the paper, this will require the participation of scientists from academia and industry who work in diverse areas, including traditional pharmacology, clinical pharmacology, pharmacodynamics/pharmacokinetic modeling, systems biology, chemistry, bioinformatics, multiscale modeling and computer science. Training new and established investigators also will be a critical element.
We encourage you to read the paper and let us know what you think about its recommendations for research and training in QSP.
I’ve been a program officer for NIGMS research and training activities for 27 years. The Molecular Biology of the Cell journal recently asked me to describe the general roles of such a position, including the challenges and rewards. My essay , which appeared in the August 1 issue, offers insight into what the job entails and how we can help our applicants and grantees.
Here’s the abstract for “A View from the NIH Bridge: Perspectives of a Program Officer”:
This essay is written from my perspective as a program officer for research and training activities at the National Institute of General Medical Sciences (NIGMS) for almost 27 yr. It gives a bird’s-eye view of the job of a program officer, which includes providing advice to applicants and grantees, making funding recommendations, overseeing grantees’ progress, facilitating scientific opportunities in specific areas of program responsibility, and shaping NIGMS and National Institutes of Health (NIH) policy. I have highlighted the numerous rewards of serving as a program officer, as well as some of the difficulties. For those who may be considering a position as an NIH program officer now or in the future, I’ve also described the qualities and qualifications that are important for such a career choice. Finally, this essay addresses some of the challenges for the NIH and the research community in the years ahead as we simultaneously face exciting scientific opportunities and tighter budgets.