NIGMS has just issued a call for Program Projects for Collaborative Research on the Basic Biology of Pluripotency and Reprogramming (P01), with an emphasis on human induced pluripotent stem (iPS) cells. We are particularly interested in studies that propose comprehensive analyses of the basic biology of pluripotency, the molecular events and mechanisms of reprogramming, and the epigenetics and epigenomics of the pluripotent and reprogrammed states.
These applications have special requirements, so please read the announcement carefully. Letters of intent are due on November 1, and applications are due on December 1.
If your research involves stem cells but isn’t appropriate for this announcement, you may submit an investigator-initiated R01 application that addresses the basic biology of stem cells and/or uses these cells as model systems to study fundamental life processes.
You may contact me at email@example.com or Marion Zatz at firstname.lastname@example.org with questions about this new opportunity or about NIGMS support for stem cell research.
It’s safe to say that the discovery that human non-embryonic cells can be reprogrammed to an embryonic stem cell-like state has created a lot of excitement in the scientific community. These cells provide a wonderful opportunity to investigate the fundamental molecular and genetic properties of pluripotent cells.
Last month, the NIGMS Council approved a new grant program that will focus on studying the basic biology of pluripotency and reprogramming, with an emphasis on human induced pluripotent stem (iPS) cells. This initiative will use the program project (P01) mechanism to support collaborative research that advances a comprehensive understanding of the basic biology of pluripotency, the molecular events and mechanisms of reprogramming, and the epigenetics and epigenomics of the pluripotent and reprogrammed states.
Once the funding opportunity announcement has been published in the NIH Guide later this summer, we will post it on the Feedback Loop site. In the meantime, I encourage you to start talking with potential collaborators and thinking about applying.
NIH Director Francis Collins announced today that the first 13 human embryonic stem cell (hESC) lines to be approved under the new NIH Guidelines for Human Stem Cell Research have been placed on the NIH Human Embryonic Stem Cell Registry, and NIH grantees may now use them. These lines were not previously eligible for NIH funding under the 2001 guidelines.
Investigators whose grants were awarded with restrictions on using the funds for hESC research should check the registry to determine if any of the lines are suitable for their projects. Please see today’s NIH Guide notice for more details, including procedures on how to request that the award restrictions be lifted.
An additional 96 lines have been submitted for inclusion in the registry. We expect that more will become eligible for use in the coming months.