Here are several new NIH Guide notices regarding applications:
New Time Limit for NIH Resubmission Applications
Revised applications must be submitted no later than 37 months after submission of the preceding version. In most cases, the clock will start at the original receipt date. For special cases, please refer to NOT-OD-10-140.
NIH to Require Use of Updated Electronic Application Forms in 2011
Submissions for deadlines after May 7, 2011, must use an updated forms package (ADOBE-FORMS-B1). For deadlines before then, applicants may use either the new forms package or the current one, ADOBE-FORMS-B. There are some exceptions: K, T, D or F series applications submitted for deadlines on or after January 25, 2011, must use the new forms package. For more information, see NOT-OD-11-008 and NOT-OD-11-007.