Each year, NIH nominates outstanding young scientists for the Presidential Early Career Award for Scientists and Engineers (PECASE), the highest honor bestowed by the U.S. government to scientists beginning their independent research careers. The scientists are selected for their innovative research record, potential to continue on this productive route and community service activities. Among this year’s PECASE recipients (nominated in 2014) are two NIGMS grantees, Tufts University’s Aimee Shen (who started her career at the University of Vermont) and Montana State University’s Blake Wiedenheft (who was the inaugural NIGMS Director’s Early Career Investigator Lecturer). Both scientists launched their labs with support from our Institutional Development Award (IDeA) program, which fosters health-related research and enhances the competitiveness of investigators at institutions in states with historically low levels of NIH funding.
Below, they answer questions about their research and community service efforts, offer advice to other early career scientists, and share their experiences with the IDeA program.
What is the focus of your research?
Blake Wiedenheft: Viruses that infect bacteria (i.e., bacteriophages) are the most abundant biological entities on earth. The selective pressures imposed by these pervasive predators have a profound impact on the composition and the behavior of microbial communities in every ecological setting. In my lab, we rely on a combination of techniques from bioinformatics, genetics, biochemistry and structural biology to understand the mechanisms that bacteria use to defend themselves from viral infection.
Aimee Shen: My lab studies Clostridium difficile, the leading cause of healthcare-associated infection in the United States. C. difficile forms metabolically dormant cells known as spores that allow the microbe to survive exit from the gastrointestinal tract of a mammalian host. My research is directed at understanding how C. difficile spores form in order to transmit infection and how they germinate and transform into disease-causing cells to initiate infection.