Funding Opportunities: Basic Behavioral and Social Sciences Opportunity Network, Highly Innovative Tools and Technology for Analysis of Single Cells

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You may be interested in these recent funding opportunity announcements:

Limited Competition: Revision Applications for Basic Social and Behavioral Research on the Social, Cultural, Biological, and Psychological Mechanisms of Stigma (R01)
(RFA-MD-13-005)

Purpose: Revise applications to incorporate basic research on behavioral and social mechanisms underlying stigma into active R01 research projects
Letter of intent due date: July 2, 2013
Application due date: August 2, 2013
NIH contacts:
Jennifer Alvidrez, NIMHD, 301-594-9567
Rebecca Ferrer, NCI, 301-594-0437
Enid Light, NIMH, 301-443-3599
Kathleen Michels, FIC, 301-435-6031

Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44)
(PA-13-140)

Purpose: Develop next-generation tools that distinguish heterogeneous states among cells and have commercial potential
Application due date: Standard dates apply
NIGMS contact: Stefan Maas, 301-594-0943

Provide Input on Challenges and Opportunities in Pharmacogenomics

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We are seeking input from the scientific community on challenges, opportunities and gaps in pharmacogenomics. Please help us shape future programs in pharmacogenomics by responding to the recently published request for information (RFI). The RFI asks for your input on several topics, such as:

  • Critical technological advances that can be applied to pharmacogenomics problems;
  • Specific tools, resources, methods and approaches needed to enhance our molecular, genetic and biological mechanistic understanding;
  • Ways to advance clinical implementation for improving health care outcomes, including safety, effectiveness, time and costs;
  • Synergies that might come from a research network;
  • Types of scientific endeavors that would best be funded by R01 grants in the field; and
  • Additional interfaces and interactions that should be developed by NIH with other funders or organizations.

Please take the time to comment on any or all of the above topics between now and the May 17 deadline. You may respond as individuals or groups. Working together, we can help advance this research area of great scientific interest and immediate health relevance.

Genomes to Natural Products RFA

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Last September, I described a concept clearance for an initiative to develop new approaches in natural products discovery that had just been approved by the NIGMS Advisory Council. The resulting request for applications on Genomes to Natural Products (U01) has now been published in the NIH Guide.

NIGMS, along with the National Center for Complementary and Alternative Medicine (NCCAM), will support multidisciplinary research to develop high-throughput, broadly applicable approaches to natural products discovery that integrate genomics, synthetic biology and bioinformatics. We anticipate that up to four awards will be made through the cooperative agreement mechanism, totaling up to $9 million in Fiscal Year 2014. For NCCAM-specific interest areas and application requirements, see NOT-AT-13-005.

Applications are due by July 17. Potential applicants are invited to participate in an optional online Q&A session on April 19 from 1 p.m. to 3 p.m. EDT. Access this event at https://webmeeting.nih.gov/rfa-gnpn/ and sign in as a “guest” to be able to submit questions.

Letters of intent are not needed, but depending on which funding component’s areas of interest are more relevant to the proposal, I strongly recommend that potential applicants e-mail me or my counterpart at NCCAM, Craig Hopp to discuss submission plans.

Macromolecular Interactions in Cells, Bioengineering Research Funding Opportunities

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You may be interested in these recent funding opportunity announcements:

These two announcements are based on a broader initiative for research on macromolecular interactions in cells in vivo. The initiative also includes an additional funding opportunity, Revisions for Macromolecular Interactions in Cells (R01).

  • Collaborations for Macromolecular Interactions in Cells (R01)
    (RFA-GM-14-004)

Purpose: Establish interdisciplinary collaborative projects to advance studies of macromolecular interactions and their relationship to function in cells, tissues and organisms

  • Research Networks for Macromolecular Interactions in Cells (U54)
    (RFA-GM-14-005)

Purpose: Establish interdisciplinary collaborative research networks to advance studies of macromolecular interactions and their relationship to function in cells, tissues and organisms

Letter of intent due date: April 30, 2013
Application due date: May 30, 2013
NIGMS contacts:
Alexandra Ainsztein, 301-594-0828
Daniel Janes, 301-594-0943
Vernon Anderson, 301-594-3827
Paul Brazhnik, 301-451-6446

Bioengineering Research Grants (BRG) (R01)
(PAR-13-137)

Purpose: Develop an innovative technology, model, technique, design or method that infuses principles and concepts from the quantitative sciences to increase our understanding of and solve problems in biological, clinical or translational science
Application due date: Standard dates apply
NIGMS contact: Pamela Marino, 301-594-3827

In addition, several new NIH Common Fund funding opportunities related to workforce development and diversity are listed at http://commonfund.nih.gov

Operating Under a Continuing Resolution and Sequestration

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At this time, we are continuing to fund noncompeting grants at 90%, which is consistent with our practice during the continuing resolutions of fiscal years 2006-2012. We are taking a conservative approach to funding competing awards until we have a budget for the rest of the year. This may occur through another continuing resolution or an appropriations bill.

When we have more information about the budgetary outlook for the remainder of Fiscal Year 2013, I will share our funding plans. I want to assure you that we are working very hard to minimize the impact on our ability to fund grants.

For more information about NIH operations under the sequester, see the blog post from NIH’s Sally Rockey and a letter to grantee institutions about the potential impact of this budget reduction.

CSR’s Percentiling Recalibration

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The Center for Scientific Review (CSR) has recently adjusted the base that a number of permanent study sections and special emphasis panels (SEPs) use to calculate percentiles for certain application types. Applications that were reviewed in a SEP meeting for the May 2013 Council round will be assigned a percentile ranking calculated from the new base. In some cases, revised summary statements will be issued for those applications missing percentile scores or with an incorrect percentile. The percentile ranking will also appear in the eRA Commons account of the principal investigator(s).

We here at NIGMS are often asked to explain how percentile rankings factor into determining which awards to make. We do not rely solely on a percentile cutoff; we consider a number of additional factors, including an investigator’s career stage, a laboratory’s other research funding, NIGMS research portfolio balance, and other programmatic priorities. For more information, see http://www.nigms.nih.gov/Research/Application/Pages/SuccessRateFAQs.aspx.

‘OXIDE-izing’ Diversity in Chemistry—and Beyond

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We are constantly seeking new ways to foster the development of a diverse and inclusive biomedical research workforce. One notable example is our partnership with the National Science Foundation (NSF) and the Department of Energy (DOE) to support a series of workshops on increasing diversity in chemistry departments.

The workshops focused on disability equity, racial and ethnic equity and gender equity. The organizing committees and workshop participants, mostly chemistry department chairs, felt that progress was made during each workshop. However, the insights and good intentions engendered by such meetings can have an all too high vapor pressure and gains can be lost. Enter OXIDE.

OXIDE, which stands for the Open Chemistry Collaborative in Diversity Equity, is a 5-year grant effort co-funded by NIGMS, NSF and DOE to address multiple areas of diversity, including gender, race-ethnicity, disability and sexual orientation. With the desire to keep the momentum gained from the previous workshops, OXIDE seeks to maintain a connection among the chairs of chemistry departments and partner with social scientists to take advantage of their findings.

OXIDE’s recurring National Diversity Equity Workshops facilitate discussion among these groups on the latest diversity research and its implications for chemistry departments. The next workshop, which is open primarily to chairs or thought leaders of the leading research-active chemistry departments, will be held April 15-16, 2013, in Arlington, Virginia. Presentation slides will be archived on the Oxide Web site.

OXIDE also partners with the American Chemical Society’s Chemical & Engineering News to conduct and publish annual faculty demographic assessments of more than 75 research-active chemistry departments, allowing for longitudinal examination of data trends.

Perhaps most importantly, OXIDE embodies the commitment of the chemistry community, NIGMS and other federal agencies to advancing diversity and inclusion. Its approaches—and findings—might be useful to other scientific communities.

Networking Theme for 2013 Training, Workforce Development, and Diversity Program Directors’ Meeting

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TWD Program Directors' MeetingA goal of our Division of Training, Workforce Development, and Diversity (TWD) is to create a community of trainers and educators dedicated to developing a well-prepared, diverse biomedical research workforce.

Toward that end, the focus of this year’s TWD Program Directors’ Meeting (link no longer available) is on networking. The meeting, to be held on June 12-14 in Chicago, will address the value of sustained networking among the grantees, students and other communities served by these programs. The meeting will enable program directors to learn more about other TWD programs; establish connections with potential new partners, especially regional “neighbors”; and collectively address the Institute’s research training objectives.

Plenary sessions and keynote talks will cover the diversity of the U.S. research workforce, STEM training in the context of NIH-funded biomedical and behavioral research, and innovative approaches for evaluating and assessing our training programs. NIGMS and NIH leaders will give overviews of the Institute’s training strategic plan and the implementation of the report from the Diversity in the Biomedical Research Workforce Working Group of the Advisory Committee to the Director, NIH.

The meeting is primarily intended for program directors and associate deans (or the equivalent) at institutions with these TWD student and predoctoral training programs: Bridges to the Baccalaureate, Bridges to the Doctorate, IMSD, IRACDA, MARC T36, MARC U-STAR, RISE, PREP, NIGMS T32 predoctoral programs and IDeA INBRE.

Online registration is open now at www.TWDNIGMS.org (no longer available) and closes May 10, 2013.

Give Input on NIH Biomedical Research Workforce Plans

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The report of the Biomedical Research Workforce Working Group of the Advisory Committee to the Director, NIH, includes recommendations that could have a broad impact on NIGMS training programs.

NIH has just issued a request for information (RFI) on implementing the working group’s recommendations. As summarized in a blog post by NIH’s Sally Rockey, the RFI seeks your input on these topics:

  • Developing individual development plans (IDPs) for those in graduate and postdoctoral training supported by NIH funds from any source,
  • The length of time NIH should provide support for graduate students,
  • Providing more uniform benefits packages for postdocs,
  • Gathering information about individuals receiving NIH support for their training,
  • Reporting by institutions of aggregate career outcomes of graduate students and postdocs on a public Web site,
  • Considering multiple career outcomes as indicators of success when reviewing training grants, and
  • Launching a dialogue with the extramural biomedical research community to assess how NIH supports the biomedical community, including faculty salaries.

I strongly encourage you and your colleagues to submit comments by the April 22 deadline, because your input is key to developing policies that serve the scientific community and improve the training experience of graduate students and postdocs.

How NIH Makes Grant Application Assignments

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Here are answers to some of the questions we’re frequently asked about grant application assignments.

Who receives applications and makes assignments?

All applications are received by the Division of Receipt and Referral (DRR) in the Center for Scientific Review (CSR). The DRR gives each application two assignments, one for review and one for funding consideration.

How are review assignments made?

Referral officers in CSR assign an application to an integrated review group (IRG), a branch of CSR that manages the review of applications in a general scientific area. The chief of the IRG or his/her representative, in consultation with scientific review officers (SROs) in the IRG, makes the final assignment to a specific scientific review group (SRG), which can be a standing study section (SS) or a special emphasis panel (SEP). An SS reviews applications in a specific topic area within the purview of the IRG. A SEP reviews applications on special topics or when conflicts of interest exist. Find an IRG, SS or SEP.

Why isn’t the study section listed on my application?

Since the application is first assigned to an IRG, the IRG abbreviation initially appears as the review assignment. This abbreviation is replaced by the SRG label once that assignment has been made. A similar process occurs with applications assigned to an NIH institute or center (IC) for review. At NIGMS, the initial assignment is to our Office of Scientific Review, followed by assignment to a specific review group and SRO.

How are assignments for funding consideration made?

The DRR assigns the application to an IC for funding consideration. In some cases, the DRR may make a secondary assignment to another IC. The assignment is based on referral guidelines developed by each IC. These describe the IC’s focus and mission areas, interests shared with other ICs, and the funding opportunity announcements that the IC supports. Other considerations may include requests made by investigators or by ICs for secondary assignments.

Why wasn’t my application assigned to the person I thought was my program director?

It’s likely that your application received a “temporary” assignment. When an IC receives an application, it assigns a temporary program director. At NIGMS, this person is Ann Hagan, our associate director for extramural activities. Once the application has been matched with the most appropriate NIGMS division, branch and program director, it will receive a final assignment.

Why was my application assigned to an IC or SS that I didn’t request?

If you have traditionally been funded by one IC and request a change to another IC, reassignment will occur only if the application is deemed a better fit with the new IC. Another factor is the IC’s program interests, as described in its referral guidelines, program announcements (PAs) and requests for applications (RFAs). Many of these announcements are only supported by one or a subset of ICs. If an application is submitted in response to a funding opportunity announcement that is not supported by the requested IC, then it can’t be assigned to that IC.

Several factors influence the likelihood that a request for review assignment to a particular SS will be honored. The most important factor is whether the proposed research is a good fit for the scientific focus of the requested SS. Like science itself, the scientific focus of an SS evolves over time. Therefore, the SS that reviewed your application 4 years ago may no longer be suitable, and the IRG may make a different assignment. The funding opportunity announcement can also play a role in the review assignment. Applications for many RFAs and PAs with special receipt, referral and/or review considerations are reviewed by SEPs organized by CSR or by IC-specific scientific review offices. If the application is responding to one of these funding opportunity announcements, it can’t be assigned to a standing SS for review.

What should I do if I don’t get a requested study section or IC assignment?

You should contact the SRO or program director who was assigned the application. If, after discussion, a reassignment is warranted, that person will facilitate the change. If you still have concerns, you should contact the DRR.

For more details on this topic, read the CSR’s The Assignment Process.