Tag: MIRA

Application and Funding Trends in Fiscal Year 2023

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NIGMS continues to support a broad range of scientific topics and investigators within its research portfolio, including support for investigator-initiated research project grants (RPGs) at institutions throughout the country. As part of its commitment to transparency, NIGMS examines and publishes data on annual trends reflected in its RPG portfolio. In this post, we review and describe investigator-level trends associated with competing R01/R01-equivalent RPGs including those in the Institute’s R35 Maximizing Investigators’ Research Award (MIRA) program.

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Webinar for the Maximizing Investigators’ Research Award (MIRA) Program for Early Stage Investigators

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UPDATE: The video and slides [PDF] for this webinar are now available.

I’m pleased to announce that the Maximizing Investigators’ Research Award (MIRA) notice of funding opportunity for early stage investigators (ESIs) (PAR-23-145) has been reissued. MIRA funding provides support for an area of research in an ESI’s laboratory that falls within the NIGMS mission. The next application due date is October 3, 2023.

We’re hosting a webinar to discuss the key features of the ESI MIRA program and to answer your questions:

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Funding Opportunity: Continuation of the ESI MIRA Program

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We’re pleased to share the notice of funding opportunity (NOFO) (PAR-23-145) to provide sustained support for biomedical research through our Maximizing Investigators’ Research Award (MIRA) (R35) program for early stage investigators (ESIs). This NOFO allows applications from ESIs proposing research within NIGMS’ scientific mission.

NIGMS has granted MIRAs to ESIs since Fiscal Year (FY) 2016. We’ve analyzed and published application and funding trends for MIRAs from FY 2019 to FY 2021 and for various funding types, including MIRA, for FY 2022. Changes in this iteration of the NOFO include:

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Application and Funding Trends in Fiscal Year 2022

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NIGMS continues to support a wide range of topics and investigators, maintaining a broad biomedical research portfolio. In Fiscal Year (FY) 2022, NIGMS received a congressional appropriation of $3,092,373,000. Consistent with the Institute’s mission, a large portion of these funds support investigator-initiated research project grants (RPGs) at institutions throughout the country. As part of its commitment to transparency, NIGMS publishes data on annual trends in its grant portfolios. In this post, we describe investigator-level trends for RPGs and review the trends associated with competing RPGs as well as those in the Institute’s Maximizing Investigators’ Research Award (MIRA) program.

NIGMS Investigator-Level Trends for Research Grants

At NIGMS, we focus on supporting a broad group of investigators. As a result, we monitor two statistics that describe our investigator pool: the cumulative investigator rate and the number of funded early stage investigators (ESIs). The number of newly funded ESIs has notably increased over recent years, and continued support for ESIs is integral to the success of the biomedical research enterprise and is a priority for the Institute. Figure 1 illustrates the number of ESIs who received their first competing NIGMS R01-equivalent grants each year between FY 2013 and FY 2022. In FY 2022, NIGMS awarded R01-equivalent grants to 319 ESIs in total: 31 investigators received R01 awards, 268 investigators received R35 (MIRA) awards, and 20 investigators received NIH Director’s New Innovator Awards (DP2s). These data include DP2s (four awards) administered by NIGMS on behalf of the NIH Office of the Director. The number of funded ESI MIRAs in FY 2022 was the largest to date, and more than four times larger than in the program’s first year. Overall, the number of funded ESIs has risen almost every year since FY 2013, with the slight decrease in the number of awards between FY 2017 and FY 2018 due in part to the introduction of the MIRA program in FY 2016 and a temporary reduction in the built-up ESI applicant pool as more ESIs received funding.

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Intent to Reissue MIRA Funding Opportunity Announcement for Early Stage Investigators (R35)

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I’m pleased to announce that the funding opportunity announcement (FOA) for the Maximizing Investigators’ Research Award (MIRA) for early stage investigators (ESIs) will be reissued in the spring of 2023. MIRA provides support for a research program in an ESI’s laboratory that falls within the NIGMS mission. For details, see NOT-GM-23-017

The reissued FOA will essentially be the same as the previous one, with a couple of minor changes:

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Webinar for the NIGMS Maximizing Investigators’ Research Award (MIRA) Program

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UPDATE: The slides [PDF] and video from this webinar are now available.

I’m pleased to announce that the Maximizing Investigators’ Research Award (MIRA) funding opportunity announcement (FOA) for established and new investigators (PAR-22-180) has been reissued. MIRA provides support for the program of research in an investigator’s laboratory that falls within the NIGMS mission. The next application due date is January 17, 2023.

We’re hosting a webinar to discuss the key features of this FOA and to answer your questions:

Friday, October 21, 12:30-2:00 p.m. ET
Zoom meeting link
Meeting ID: 160 903 8368
Passcode: NIGMS

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Application, Review, Funding, and Demographic Trends for Maximizing Investigators’ Research Awards (MIRA): FYs 2019-2021

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In this Feedback Loop post, we revisit our previous analysis of application, review, funding, and demographic trends for the Maximizing Investigators’ Research Award (MIRA) program over Fiscal Years (FYs) 2019 to 2021. We look at trends for applicants by race/ethnicity and by gender. Due to privacy requirements and small numbers, applicants from underrepresented racial and ethnic groups in biomedical research (Black or African American, Hispanic or Latino, American Indian or Alaska Native, Native Hawaiian and other Pacific Islander) are combined into a larger group that can be reported. Because of the small applicant numbers, we’re unable to show intersectional analyses of race/ethnicity and gender or analyses of applicants with disabilities. 

Table 1 shows the number of new awards made and associated award rates by fiscal year for Established Investigators (EIs) and Early Stage Investigators (ESIs).

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NIGMS Continues and Expands Its MIRA Program

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We’ve issued a funding opportunity announcement (FOA) (PAR 22-180) to provide sustained support for biomedical research through our Maximizing Investigators’ Research Award (MIRA) program. This FOA allows applications from eligible NIGMS-funded investigators and from New Investigators proposing research within the scientific mission of NIGMS. The FOA also allows renewal applications from all eligible MIRA grantees (established and ex-Early Stage Investigators). Program directors (PDs)/principal investigators (PIs) who are currently Early Stage Investigators (ESIs) should apply through the ESI MIRA FOA and not to this announcement.

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Application and Funding Trends in Fiscal Year 2021

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NIGMS maintains a diverse biomedical research portfolio, supporting a wide range of topics and investigators. In Fiscal Year (FY) 2021, NIGMS received a congressional appropriation of $2,991,417,000. As part of the Consolidated Appropriations Act, 2022, this budget increased by 3.4% to $3,092,373,000 for FY 2022. The majority of these funds support research project grants (RPGs) at research institutions throughout the country. In alignment with its commitment to transparency, NIGMS publishes data on annual trends in its grants portfolio. In this post, we first describe investigator-level trends for RPGs, then review the trends associated with competing RPGs, and lastly examine trends in the Institute’s Maximizing Investigators’ Research Award (MIRA) program.

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Do MIRA Investigators Apply for More Grants From Other NIH Institutes and Centers Than R01 Investigators?

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NIGMS’ Maximizing Investigators’ Research Award (MIRA) provides investigators with flexibility and stability for their research programs. Investigators who receive MIRA support must dedicate 51% of their research effort toward the grant and are ineligible to apply for or receive other NIGMS research support (with some exceptions). One question frequently asked is whether the NIGMS funding restriction changes the likelihood that MIRA grantees will submit applications to other NIH institutes and centers (ICs). In this post, we compare data on post-award grant applications from NIGMS-funded investigators.

To compare application behavior between MIRA and R01-funded investigators, we created sets of both established (EI) and early stage (ESI) investigators supported by NIGMS R01s (called the comparator group) who have not received a MIRA. The EI comparators were matched according to race/ethnicity, gender, time since acquisition of first R01, and average annual NIGMS funding. For the ESI comparator group, we used all ESI NIGMS R01 awardees.

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