Tag: Research Resources

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Sustaining a Community Resource for Cell Lines and DNA Samples

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Cryogenic tanks filled with liquid nitrogen and millions of vials of frozen cells. Credit: Coriell Institute for Medical Research.
Cryogenic tanks filled with liquid nitrogen and millions of vials of frozen cells. Credit: Coriell Institute for Medical Research.

We have just funded a new, 5-year award to continue operation of the NIGMS Human Genetic Cell Repository, an important resource for the scientific community since 1972. The repository contains more than 11,300 human cell lines and 5,700 DNA samples derived from them. These high-quality, well-characterized and rigorously maintained resources, which you can order for a nominal fee, include:

  • Specimens from individuals with inherited diseases, apparently healthy individuals and those of diverse geographic origins that are divided equally between those from males and those from females.
  • A group of 39 induced pluripotent stem (iPS) cell lines that carry disease gene mutations or that are normal control iPS cell lines.
  • An inherited disease collection that represents almost 900 disorders.

Last year, 1,500 scientists received more than 5,000 cell lines and 40,000 DNA samples. I encourage you to peruse the catalog Link to external web site and consider whether these specimens may be useful in your research program.

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Report and Recommendations from the Future of Structural Biology Committees

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NIGMS Advisory Council Meeting: Report of the NIGMS Future of Structural Biology Committees
Dr. Leemor Joshua-Tor’s presentation of the report begins at 00:36:22 on the archived videocast of the National Advisory General Medical Sciences Council meeting.

I previously told you about the formation of two committees focused on Protein Structure Initiative (PSI) transition planning. These committees were charged with identifying high priorities for future NIGMS investments in structural biology and determining what unique resources and capabilities developed during the PSI should be preserved to address the needs of the scientific community. Dr. Leemor Joshua-Tor, one of the committee co-chairs, presented the groups’ report at the National Advisory General Medical Sciences Council meeting on January 23.

The committees’ recommendations for preserving PSI resources that the committees felt will be important for the community in the future include:

  • Support for a modest number of protein expression resources to serve the needs of the community.
  • Continued support for a materials repository similar to the one that has been supported through PSI.
  • Possible continued support for a structural biology knowledgebase Link to external web site.

The committees identified these areas as high priorities for the future of structural biology:

  • Continued support for synchrotron beamlines for crystallography.
  • Support for modern cryo-EM resource centers.
  • Continued support for NMR resources for structural biology.
  • Support for the integration of structural biology methods.
  • Support for collaborative, multi-investigator efforts in membrane protein and large macromolecular assembly structure determination.

We’re now developing plans for implementing the report’s recommendations.