The successful entry and retention of new investigators into biomedical research is a priority for us, and the renewal rate of this group’s first R01 research grants is an important indicator for this goal. Here are the results of an analysis I did of the first competing renewal rates for new and established investigators.
Figure 1 shows that the first competing renewal rate of new investigators’ first NIGMS R01 or R29 grants has declined over the past 10 years. This trend is similar to the one for overall NIGMS R01 application success rates.
Figure 2 gives a more complete picture of the renewal history of new investigators’ NIGMS R01 and R29 projects. In addition to the renewal rate (also shown in Figure 1), it shows the percentage of projects for which at least one renewal application was submitted but was not successfully renewed as well as the percentage of projects for which no renewal application was submitted.
Figure 3 shows that success in renewing an NIGMS-funded R01 grant correlates positively with how long the grant has been active.
Since first renewals have lower success rates than subsequent renewals, Figure 4 addresses whether new investigators seeking to renew their first R01 grants are competitive with established investigators who are renewing long-term and/or new projects. The figure shows that the renewal rate for all projects from established investigators, including new as well as long-term projects, is higher than the renewal rate of projects from new investigators (46 percent in the left column versus 36 percent in the right column). However, when focusing only on the first renewals of new projects (in the middle and right columns), new investigators are renewing at a higher rate than are established investigators (36 percent versus 30 percent).
Figure 5 shows the relative success of new and established investigators in renewing new projects as a function of the percentile score obtained on the initial award. As the “Paid” sections of the bars indicate, for each of the percentile groups, the overall renewal rate for new investigators’ new R01s was higher than that for established investigators’ new R01s.
Recognizing the importance of new investigators in sustaining the vitality of biomedical research, we give special consideration to applications from them, and in some cases, we fund these applications at percentiles beyond those for most established investigators. The data in Figure 5 supports this practice by showing that the renewal rates of new investigators whose original applications scored at or above the 20th percentile are about the same as, or higher than, those for new and established investigators whose original applications scored in the 0-9th percentile range.
More About This Analysis
This analysis includes Recovery Act projects and excludes withdrawn applications and multi-principal investigator grants.
R01 projects: Research project grants.
R29 projects: First Independent Research Support and Transition (FIRST) awards, R01-type research project grants awarded to new investigators available from 1987 to 1998.
Renewal rate: Percentage of grants that were successfully renewed by the date of this analysis (end of Fiscal Year 2014), regardless of whether a new or amended competing renewal application was funded.
Grant year: Grant year in which the renewal R01 application was submitted.
New investigator: An individual who has not previously competed successfully as a program director/principal investigator for a substantial NIH independent research award (see http://grants.nih.gov/grants/glossary.htm#NewInvestigator).