More Information About New and Early Stage Investigator MIRA Outcomes

There has been ongoing discussion—both here and in the general scientific community—related to the first MIRA awards to New and Early Stage Investigators (NI/ESI). One question that arose was why applications were administratively withdrawn. Both the NIH Center for Scientific Review and multiple NIGMS staff members, including the program director with a portfolio of grants closest to the applicant’s area of science, screened the applications. Of the withdrawn applications, a majority (~80%) were returned prior to review because they proposed research that fell outside of the NIGMS mission. Others were withdrawn because the applicant was not eligible for the FOA. After review, some applications were withdrawn because the PI accepted another award that was mutually exclusive with the MIRA. As recommended on the MIRA website and elsewhere, we encourage anyone who intends to apply for the Early Stage Investigator MIRA to discuss their plans with the appropriate NIGMS program director to determine whether the proposed research area is within the mission of the Institute and if the applicant is eligible to apply.

A major NIGMS goal is to support a broad portfolio that is diverse in research topics, approaches, institutions and investigators. This means we are looking carefully at the outcomes of awards, including gender and race/ethnicity data. We are also trying to take proactive steps to prevent bias during the review, for instance by covering the topic as part of reviewer orientations that take place several weeks before the MIRA study sections meet.

In our recent summary of MIRA applicant and awardee demographics, we looked to see how applications from underrepresented groups compared to those from well-represented groups (White and Asian). The p-value for a difference between the distributions of funded and unfunded applications from these groups was 0.63, meaning that there was no statistically significant difference between the two groups. We also compared the MIRA success rates to those of ESI applicants for NIGMS R01s in fiscal years (FY) 2011-2015 (Table 1).

When the race and ethnicity categories are broken down further, there is a statistically significant (p < 0.01) difference when comparing only the percentages of White and Asian applicants who were funded and not funded, as has been noted by others. Table 2 shows success rates for different race/ethnicity groups for NIGMS ESI R01 applicants from FY 2011-2015 and the FY 2016 NI/ESI MIRA cohort.

In terms of gender, the success rate for men was 30% while that for women was 24% (p = 0.48). Women represented 27% of the applicants and 24% of the grantees. For NIGMS ESI R01 applicants, the relative success rates for men and for women have fluctuated over the last several years (Table 1), yet there is no statistically significant difference when comparing the mean success rates for men and women (p = 0.72).

Overall we awarded 93 NI/ESI MIRAs. In a single year’s cohort with these small numbers, it can be difficult to distinguish meaningful differences and trends. We will continue to study the initial outcomes of the MIRA program, which is still in its pilot phase, paying close attention to the various stages of review and the funding decision process to mitigate possible sources of bias and to help ensure that we support a broad and diverse research portfolio.

*Includes applicants who were New Investigators at the assistant professor or equivalent level.
†White and Asian applicants.
‡American Indian/Alaska Native, Black or African-American, Hispanic/Latino and Pacific Islander.
*Includes applicants who were New Investigators at the assistant professor or equivalent level.
‡ American Indian/Alaska Native, Black or African-American, Hispanic/Latino and Pacific Islander.

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