Next Deadline for Collaborative Science Supplement Requests

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The next application deadline for the Administrative Supplements for Collaborative Science (SCS) program is May 15, 2012. Applications may be submitted on paper, as described in the announcement, or through the electronic submission pilot for administrative supplement requests.

The SCS program provides supplements to support new collaborations that will advance the aims of the parent R01 or R37 grant, which must be actively funded through at least November 30, 2013. The most compelling supplement requests propose to take advantage of new scientific opportunities and involve collaborators from other disciplines.

SCS awards are very competitive, so you should talk to your program director to assess whether your ideas fit this program before writing an application.

Register Now for First TWD Division Grantee Meeting

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TWD 2012 Meeting bannerThe first meeting of NIGMS Division of Training, Workforce Development, and Diversity (TWD) grantees will be held on June 12-15, 2012, in San Antonio, Texas. The meeting will provide TWD grantees with the opportunity to meet NIGMS program, review and grants management staff as well as incoming NIGMS Director Chris Kaiser.

General sessions planned for this year’s meeting include discussions about the Institute’s strategic plan for training and the vision of the new TWD division. There will also be “how to” sessions on various topics such as developing an evaluation plan, helping students transition to training programs at research-intensive institutions, and building effective business offices for managing TWD grants.

The 2012 meeting is intended for grantees of the following student and postdoctoral development programs:

  • Predoctoral T32 training programs
  • IDeA Networks of Biomedical Research Excellence
  • Bridges to the Baccalaureate
  • Bridges to the Doctorate
  • Initiative for Maximizing Student Development
  • Institutional Research and Academic Career Development Award
  • MARC Ancillary Training Activities
  • MARC Undergraduate Student Training in Academic Research Award
  • Postbaccalaureate Research Education Program
  • Research Initiative for Scientific Enhancement

Meeting registration is open until May 14, but seating is limited, so we encourage you to sign up soon.

We hope to see you in June!

Inside the Budget Process

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When a new appropriation is passed, we are often asked how soon awards will be made and other implications of the funding level. So we thought we’d offer a description of the 3-year budget process, including an explanation of what we need to do to make awards once we have an appropriation.

The Federal budget process has three main phases: formulation, presentation (to Congress) and execution. From the beginning of the budget formulation phase to the end of the execution phase, the process takes almost 3 years.
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The Federal budget process has three main stages: formulation, presentation (to Congress) and execution. From the beginning of the budget formulation stage to the end of the execution stage, the process takes almost 3 years.

Stage 1a: Budget Formulation at the NIH Level (usually June through October of year 1)

NIH develops an agency-wide budget request and submits it to the Department of Health and Human Services (HHS). HHS reviews the request and provides an allowance of funds with policy guidelines.
Negotiations follow between NIH and HHS, resulting in a final budget allowance that HHS submits to the Office of Management and Budget (OMB). OMB reviews the HHS request along with all other department budgets and issues another budget allowance with policy guidelines.

After more negotiations, OMB issues a final allowance. NIH reworks its budget to fit this allowance and its guidelines, then makes allocations to each institute and center.

Stage 1b: Budget Formulation at the Institute/Center Level (usually November through January of year 2)

Each institute or center allocates its budget on a mechanism-by-mechanism basis (i.e., separate budget allocations for research grants, center grants, training grants, etc.) following the guidance provided by OMB and NIH. For an example, see this budget mechanism table.

Typical guidance examples include:

  • X% reduction on noncompeting research project grants.
  • The same overall average cost for competing grants as in the previous year.
  • The same number of trainees supported as in the previous year.

Stage 2: Budget Presentation to Congress (January through September of year 2)

The President issues his budget request for the upcoming fiscal year, usually in early February.

Each institute or center then issues a Congressional justification (CJ) document defending its portion of the President’s budget request to Congress. The CJ displays budgets for the prior year, current year and upcoming year, along with other tables and program descriptions.

Next, usually in the spring, the NIH Director and selected institute or center directors attend Congressional hearings with the House and Senate subcommittees in charge of NIH appropriations. The NIH Director presents an opening statement and the committee members ask questions in person and later in writing. All directors submit written opening statements and may have to answer questions even if they don’t testify at a hearing.

The House and Senate subcommittees develop a budget allowance for each institute or center, including “report language” identifying any specific guidance and significant items they wish to address. This is followed by a conference to work out the differences and finally by an appropriation to each institute or center that the President signs into law.

If a budget is not approved by the start of the fiscal year (October 1), Congress will usually pass a continuing resolution to provide temporary funding. Under a standard continuing resolution, current operations may continue at a specified funding level, including the funding of some grants, but new programs cannot be started.

Stage 3: Budget Execution of the Current-Year Appropriation (October 1 through September 30 of year 3)

Once an appropriation is signed, several additional steps must take place before we can begin funding grants. For example, we need to submit documents to OMB so it can make funds available to us on a quarterly basis. Also, we need to implement the policy guidance and modify our grants management systems accordingly.

We then allocate the funds by mechanism, applying current policies and determining the cost of commitments within those mechanisms. We allocate the bulk of the remaining competing funds to investigator-initiated research project grants (RPGs), with a small portion going to special initiatives. RPG funds are disbursed to the NIGMS divisions three times per year, following each advisory council meeting. The divisions’ budgets are based on the specific applications assigned to them and their scores. Divisions make funding decisions that take into consideration the applications’ scientific merit, new investigator support, area of research and other parameters.

Outsourcing Lab Procedures: What Are Your Needs and Ideas?

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Do you want to have more or easier access to state-of-the-art technologies and methodologies for your research? Are there specific types of non-clinical laboratory procedures that you wish were available through an outsourcing service?

If you answered “yes” to either of these questions, then please consider responding to our Request for Information (RFI): Priorities for Outsourcing of Laboratory Procedures. The RFI will help us identify research areas, such as assays, measurements and computational and data management tasks, that could be developed into outsourced services perhaps by small businesses and possibly supported through new funding opportunities.

Responses, which are voluntary and anonymous, should be submitted electronically (no longer available) by May 1, 2012.

UPDATE: The response deadline has been extended to May 15 (NOT-GM-12-110).

Common Fund Opportunities for Support and Giving Input

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You may be interested in the following NIH Common Fund-related opportunities:

Use-Oriented Basic Research: Change Mechanisms of Behavioral Social Interventions (Admin Supp)
(PA-12-119)

Purpose: Fund administrative supplements to study possible mechanisms of action of behavioral or social interventions
Application due date: May 15, 2012
NIH contacts:
Lisa Onken, NIDA, 301-443-0107
Melissa Riddle, NIDCR, 301-451-3888
Varda Shoham, NIMH, 301-443-8694

Request for Information (RFI): Challenges and Opportunities in Single Cell Analysis for Biomedical Research
(NOT-RM-12-018)

Purpose: Provide input to an NIH Common Fund working group charged with identifying challenges and emerging opportunities related to single-cell analysis
Response due date: April 12, 2012
Send responses to single_cell@mail.nih.gov

Fiscal Year 2013 Budget Hearings Under Way

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The House hearing on the Fiscal Year 2013 budget request for NIH happened on Tuesday, March 20, and the Senate one will occur this Wednesday, March 28.

My written statement to the House Subcommittee on Labor-HHS-Education Appropriations highlights recent research advances in model organism research, systems biology, AIDS-related structural biology, disease modeling, chemical synthesis and pharmacogenomics. I also mention our ongoing efforts to strengthen the biomedical research workforce.

NIH Director Francis Collins’ written testimony on the Fiscal Year 2013 budget is also now available.

These statements are part of the process that ultimately leads to an appropriations bill for NIH, including NIGMS. In a future post, we will describe the entire budget process so that you can better understand how and when we make funding decisions.

Upcoming NIGMS Training Grant (T32) Application Deadline

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The next submission date for NIGMS predoctoral T32 applications is May 25. If you plan on submitting an application, please see my earlier post with reminders about mandatory requirements related to recruitment and retention plans for students with disabilities, training in the responsible conduct of research and NIGMS-specific guidelines. Feel free to contact me with additional questions.

Reflecting on Our Golden Anniversary

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NIGMS 50th Anniversary BannerLast October, I told you that NIGMS would be commemorating its 50th anniversary in 2012.  We hope you will help us mark this milestone by participating in our upcoming anniversary events, which include sessions at scientific meetings and a special symposium on the NIH campus that will feature talks by three outstanding NIGMS-funded investigators as well as poster presentations by NIGMS-supported undergraduate, graduate and postdoctoral scientists.

Another way to get involved is to provide a personal reflection about NIGMS. I want to thank those who have already sent theirs and encourage everyone to take a few minutes to read them. I hope they will inspire you to send in one of your own. We welcome individual or group contributions of any length and in any format (text, audio or video).

New Funding Opportunities: Studying Macromolecular Interactions in Cells, Small Business Alzheimer’s Disease Research

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You may be interested in the following recently issued funding opportunity announcements:

Collaborations for Macromolecular Interactions in Cells (R01)
(RFA-GM-13-004)

Purpose: Establish interdisciplinary collaborative projects to advance studies of macromolecular interactions and their relationship to function in cells.
Letter of intent due date: May 14, 2012
Application due date: June 14, 2012
NIGMS contacts:
Division of Biomedical Technology, Bioinformatics, and Computational Biology
Paul Brazhnik, 301-451-6446
Division of Cell Biology and Biophysics
James Deatherage and Alexandra Ainsztein, 301-594-0828
Division of Genetics and Developmental Biology
Daniel Janes, 301-594-0943
Division of Pharmacology, Physiology, and Biological Chemistry
Vernon Anderson, 301-594-3827

Research Networks for Macromolecular Interactions in Cells (U54)
(RFA-GM-13-005)

Purpose: Establish interdisciplinary collaborative research networks to advance studies of macromolecular interactions and their relationship to function in cells.
Letter of intent due date: May 14, 2012
Application due date: June 14, 2012
NIGMS contacts:
Division of Biomedical Technology, Bioinformatics, and Computational Biology
Paul Brazhnik, 301-451-6446
Division of Cell Biology and Biophysics
James Deatherage and Alexandra Ainsztein, 301-594-0828
Division of Genetics and Developmental Biology
Daniel Janes, 301-594-0943
Division of Pharmacology, Physiology, and Biological Chemistry
Vernon Anderson, 301-594-3827

Small Business Alzheimer’s Disease Research (SBIR[R43/R44])
(RFA-OD-12-003)

Purpose: Solicit Small Business Innovation Research (SBIR) grant applications in the area of Alzheimer’s disease.
Letter of intent due date: March 30, 2012
Application due date: April 30, 2012
NIGMS contact: Scott Somers, 301-594-3827

Small Business Alzheimer’s Disease Research (STTR[R41/R42])
(RFA-OD-12-004)

Purpose: Solicit Small Business Technology Transfer Research (STTR) grant applications in the area of Alzheimer’s disease.
Letter of intent due date: March 30, 2012
Application due date: April 30, 2012
NIGMS contact: Scott Somers, 301-594-3827

Budget Update for Fiscal Years 2012 and 2013

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The Fiscal Year 2012 appropriation provides NIH with $30.86 billion and NIGMS with $2.43 billion. The NIGMS figure represents an increase of 19% over Fiscal Year 2011 due to an increase in funds for programs transferred to NIGMS from the former National Center for Research Resources.

NIGMS will implement its fiscal management policies in a manner consistent with NIH’s fiscal policies:

  • Noncompeting research project grants (RPGs), both modular and nonmodular, will be issued with no inflationary increases for Fiscal Year 2012 and all future years, except for special needs such as equipment and added personnel. Fiscal Year 2012 competing awards will be held at an average cost comparable to Fiscal Year 2011 competing awards. Fiscal Year 2012 awards that have already been issued will be revised to adjust the award level in accordance with the above policies.
  • For Ruth L. Kirschstein National Research Service Awards (NRSA), all stipend levels will increase by 2%.

The President’s Fiscal Year 2013 budget request, which was released on February 13, maintains the current NIH budget of $30.86 billion, similar to the Fiscal Year 2011 and Fiscal Year 2012 appropriations. The President’s Fiscal Year 2013 request for NIGMS provides a budget of $2.38 billion, a slight decrease from Fiscal Year 2012 but comparable to the Fiscal Year 2011 level of support. The Fiscal Year 2013 request includes a decrease for the IDeA program, which received a 1-year increase in Fiscal Year 2012.

Details of the budget request for NIH are posted on the NIH Office of Budget Web site. The NIGMS request is detailed in our Fiscal Year 2013 budget justification, which includes a budget mechanism table, budget graphs, a Director’s overview and a justification narrative.