Tag: Sepsis Research

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Notice: NIGMS Support to Utilize Data and Biospecimens Generated by the ARDS, Pneumonia, and Sepsis Phenotyping Consortium

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We’ve issued a new notice: NIGMS Support to Utilize Data and Biospecimens Generated by the ARDS, Pneumonia, and Sepsis (APS) Phenotyping Consortium (NOT-GM-24-018). The purpose is to inform investigators that we’ll support studies that fall within the NIGMS mission and utilize biospecimens or data generated from the APS Consortium.

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Funding Opportunities: The ARDS, Pneumonia, and Sepsis Phenotyping Consortium

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We want the research community to know about two funding opportunity announcements (FOAs) that NIGMS has joined as part of an NHLBI initiative to support the formation of a multisite study, the Acute Respiratory Distress Syndrome (ARDS), Pneumonia, and Sepsis Phenotyping (APS) Consortium. The study seeks to better define the heterogeneity underlying critical illness syndromes and to identify the mechanisms of illness development and recovery, as well as relationships and overlap between these syndromes. The FOAs are:

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Funding Opportunity: R21/R33 to Test Existing or New Biospecimens from Sepsis Patients

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We’ve issued a new funding opportunity announcement (FOA): Exploring the Scientific Value of Existing or New Sepsis Human Biospecimen Collections (R21/R33 – Clinical Trial Not Allowed) (PAR-21-077). This FOA aims to promote the optimal use, testing, and sharing of patient-derived materials. It stems from recommendations of the NAGMSC working group on sepsis and input from the scientific community for strategies to rebalance NIGMS’ investment in sepsis research.

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NIGMS Priorities for Small Business Development of Sepsis Diagnostics and Therapeutics

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Last summer, we published a notice of information on our priorities for sepsis research that applies to all active NIGMS funding opportunity announcements. We’ve now published a notice of special interest (NOT-GM 20-028) to promote early-stage research and development projects through the NIH SBIR/STTR program. 

We’re interested in receiving applications from small businesses or from small businesses and their academic partners that propose to develop novel tools and technologies for sepsis research, detection, and treatment. We’re specifically interested in diagnostic tools, predictive clinical algorithms, and technologies to facilitate molecular phenotyping of sepsis patients.

If you have any questions about NIGMS priorities for small business development of sepsis diagnostics and therapeutics, please contact me. 

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Request for Information on Human Biospecimens for Research on Sepsis

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NIGMS wants to advance our understanding of sepsis in order to accelerate improved diagnosis and treatment strategies. Based on the recommendations of our National Advisory General Medical Sciences Council Working Group on Sepsis, we intend to continue our support of fundamental discovery and mechanistic science relevant to sepsis. We recently identified the Institute’s specific priorities for sepsis research in an NIH Guide notice (NOT-GM-19-054). Additionally, the Working Group recommended that NIGMS encourage the use of human clinical materials to facilitate more rapid progress toward better identification, staging, and endotyping of the disease.

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Notice of Information on NIGMS Priorities for Sepsis Research

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At the recent National Advisory General Medical Sciences (NAGMS) Council meeting, the Recommendations of the NAGMS Working Group on Sepsis were presented. As one of our first responses to the recommendations of this working group, NIGMS has published a Notice of Information on NIGMS Priorities for Sepsis Research.

The Notice of Information provides potential applicants with details of specific research topics that are of special interest to NIGMS as well as those that are considered to be of low priority for funding.

If you have any questions about NIGMS Priorities for Sepsis Research, please contact me.

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Recommendations of the NAGMS Working Group on Sepsis

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Sepsis is a serious condition that affects about 1.7 million people and causes about 270,000 deaths annually in the U.S. Because it involves multiple organ systems, it is also one of the clinical research areas supported by NIGMS. Despite decades of research, sepsis remains a poorly understood condition with limited diagnostic tools or therapeutic interventions.

Nearly a year ago, we established a working group of our Advisory Council to advise us on how best to advance sepsis research. At last week’s Council meeting, Dr. John Younger and Dr. Monica Kraft, co-chairs of the working group, presented the group’s recommendations:

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