You may be interested in this funding opportunity announcement from the NIH Common Fund:
NIH Director’s Transformative Research Awards (R01)
(RFA-RM-12-017)
Purpose: Support groundbreaking, exceptionally innovative, original and/or unconventional research with the potential for major impact in a broad area of biomedical or behavioral science
Letter of intent due date: August 21, 2012
Application due date: September 21, 2012
NIH contact: Ravi Basavappa, 301-435-7204
Applying for these so-called innovative awards seems to be a waste of time! Nobody really understands what the reviewers are looking for. The review criteria are very vague, and you have folks that are not experts in your field judging whether your proposal is innovative or not. It seems that your name and scientific affiliations play a bigger role in determining your success (take a look at past recipients and their “interesting” proposals). Comments from reviewers don’t really help PIs determine whether an unfunded application stands a chance if revised and submitted anew.