Category: Meetings/Events

60th Lindau Nobel Laureate Meeting Promises to Be a ‘Dynamite’ Event

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This year, I’m the lucky NIGMS program director attending the 60th Annual Lindau Nobel Laureate Meeting in Lindau, Germany. Like John Schwab, who traveled with last year’s group, my main job is to help the 16 super-energetic, really smart graduate students we sponsored interact with each other, hundreds of their peers from all over the world and, of course, dozens of Nobel laureates.

60th Lindau Nobel Laureate Meeting

The Lindau meeting, which started in 1951, is designed to “educate, inspire and connect” generations of scientists by bringing together Nobel laureates with young researchers. Unlike last year’s meeting, which focused on chemistry, this year’s is more interdisciplinary. It showcases all three of the Nobel Prize natural science fields: chemistry, physics and physiology or medicine.

As you might imagine, the competition for student slots is fierce, with more than 40,000 applying for 650 slots this year. The U.S. contingent consists of 75 students supported by the Oak Ridge Associated Universities (ORAU), the National Science Foundation, the Department of Energy, Mars (the company, not the planet!) and NIGMS/NIH.

It’s quite appropriate that NIGMS is involved in this program again this year. Our portfolio of funded research is extremely diverse, including a lot in chemistry and physics. After all, an interdisciplinary approach can help us better address problems relevant to human health. And around NIH, NIGMS is also widely called the “Nobel Prize Institute”—we’ve funded the Nobel Prize-winning of research of 73 laureates, and some of them are here in Lindau.

So far, the trip is going pretty well. We’re surrounded by World Cup fever! We haven’t had much of a chance to meet the laureates yet, since the opening ceremony was just on Sunday. I know that much of the close laureate-student interactions will take place through small group discussion sessions set up for this purpose.

I truly feel fortunate to be here—for the interactions, the interdisciplinary science and what I anticipate will be really inspiring lectures by the laureates. But even if you can’t be here, you can still watch the scientific proceedings online and follow the meeting using a variety of social media.

Post submitted from Lindau, Germany, on Monday, Jun 28, 2010 6:25 PM CEST

Beyond Bio2010

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Beyond Bio2010Last month, I attended the “Beyond Bio2010” conference held at the National Academy of Sciences. The meeting highlighted the progress made in implementing the Bio2010 recommendations, chiefly to transform undergraduate biology education by using the quantitative sciences (mathematics, chemistry, physics, engineering and computer sciences) to study biology and vice versa.

The 2-day meeting, which was held in the same room that the Bio2010 report was publically released in 2002, primarily consisted of teams of biology, math and computer sciences faculty discussing strategies used by their institutions to reform science curricula. Among the efforts that really caught my attention were those that:

  • Assessed student learning outcomes and showed improvement as a result of integrating math, physics, chemistry and computer science into biology;
  • Established new interdisciplinary majors or minors in areas like bioinformatics;
  • Described efforts to break down “departmental silos” through collaborations among biology, math, chemistry and other faculty;
  • Trained faculty for an integrated pedagogical approach (for a resource, see The National Academies Summer  Institutes on Undergraduate Education in Biology); and
  • Discussed the need for the administration to formally recognize faculty who reformed the curricula.

In addition, I presented a summary of NIGMS-supported efforts, namely the MARC Curricular Improvement grant, a competitive mechanism for eligible institutions to implement Bio2010 recommendations. The inclusion of all undergraduate students, with a focus on historically unrepresented populations, was a significant theme of the conference. In fact, I was delighted to see one of our MARC Curricular Improvement grantees from the University of Puerto Rico talk about her institution’s efforts on this front.

A unique feature of the conference was that several undergraduate students also presented posters on their interdisciplinary biology and mathematics research. Their posters showed math majors collecting samples in a stream and biology majors performing mathematical modeling. A faculty attendee at the conference noted that when he walked around and listened to the student presenters, he really could not figure out who was a math major and who was a biology major—a desired outcome of Bio2010!

If you are interested in finding more details about “Beyond Bio2010,” a report of the conference is slated to be published in the Fall 2010 issue of CBE—Life Sciences Education.

Finding Synergy Between Math and Biology

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Frontiers in Mathematical Biology:
NSF-NIH PIs Meeting 2010 posterLast week, I attended the PI’s meeting for the Joint DMS/NIGMS Initiative to Support Research in the Area of Mathematical Biology, a program managed by us and NSF’s Division of Mathematical Sciences. A key goal of the program is to bring mathematicians and new mathematical approaches into the core of biological and biomedical research.

I was a grantee of this program before I came to NIGMS, so it was interesting to see how the program has evolved and to meet other scientists finding synergy between math and biology.

During the two-day meeting, researchers and students supported by the program shared their experiences, exchanged ideas and explored new collaborations in the field of mathematical biology. Their oral and poster presentations covered a spectrum of topics, from protein and RNA structure prediction to modeling biological complexity and statistical inference. The meeting also featured six brainstorming breakout sessions that helped the program officials identify future opportunities and challenges for the field.

Here are few ideas that caught my attention:

  • Several speakers emphasized that the quest for stimulating the innovative use of mathematics should not undermine the application of well established mathematical approaches in biology.
  • Dynamical systems theory, which describes how complex networks change over time, suggests that the architecture underlying a biological network’s control system may have been evolutionary selected to support the delicate balance between robustness and efficiency.
  • Methods for studying the spread of infectious diseases could also be used to study the spread of emotional states (depression, happiness, etc.).

If you are interested in mathematical biology, visit the meeting Web site—it will be updated soon with the meeting abstracts, slides and photos. If you would like to apply for funding for mathematical biology research, look for an announcement about the program’s next solicitation on the Feedback Loop around the end of July.

A Meeting of Scientific Minds: Quantitative and Systems Pharmacology

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Logo for Quantitative and Systems PharmacologyRegistration is now open for our second Quantitative and Systems Pharmacology Workshop, which will be held September 9-10 on the NIH campus in Bethesda, MD. The meeting is intended primarily for pharmacologists, pharmacokinetic/pharmacodynamic modelers, systems biologists and others working in fields relevant to this emerging discipline.

I first announced plans for the workshop on the Feedback Loop, and your comments both to the post and to the organizing committee helped us develop the agenda. This year’s scientific talks, researcher perspectives, panel discussions and poster presentations will focus on key questions related to the integration of pharmacology and systems biology and how it can aid our understanding of drug actions and drug discovery. Specific questions range from how we articulate a vision for systems pharmacology to what needs to happen to achieve that vision.

The meeting’s co-chairs, Peter Sorger of Harvard Medical School and Sandra Allerheiligen of Merck, Inc., along with the organizing committee have put together an exciting group of confirmed speakers who represent academia, industry and the many disciplines relevant to systems pharmacology. Please note that we are still adding specific talk titles and soliciting poster presentations.

Registration is free, but slots are limited—don’t postpone registering if you want to attend!

Video from Postdoc Workshop Now Available

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Marion Sewer, University of California, San DiegoAs you may recall from an earlier Feedback Loop message, NIGMS hosted its first workshop to help postdocs successfully transition to independent positions. We just posted videos for all the presentations.

The two-day career development event at NIH brought together 150 postdoctoral fellows from diverse backgrounds to discuss a wide range of topics, including applying and interviewing for jobs; establishing a lab and getting that first grant; and balancing research with teaching, family and other commitments. Meeting attendees also had the opportunity to ask panelists questions about their personal experiences and get other valuable career advice.

So far, we have received a lot of positive feedback from participants and presenters. If you have additional comments, please feel free to post them here or e-mail me.

Save the Date: Commemorating the Life and Accomplishments of Ruth Kirschstein

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Ruth Kirschstein, M.D.Since I first wrote about the death of former NIGMS director Dr. Ruth Kirschstein, plans have progressed for a daylong commemorative event on Monday, May 17, at NIH. The program will include several remembrances as well as scientific presentations and posters by recipients of the Ruth L. Kirschstein National Research Service Award.

I will update you when the final program is available.

Capitol Hill Briefing on Basic Research

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Investing in Discovery slide

Last week, I gave a briefing to congressional staff members and other interested parties about the role of basic science in biomedical research. The event was sponsored by the Ad Hoc Group for Medical Research and the Congressional Biomedical Research Caucus.

My talk, titled “Investing in Discovery: The Impact of Basic Research and the Role of the National Institute of General Medical Sciences,” focused on three themes:

  • The tremendous unity of biology at the molecular level, which enables researchers to use model organisms for discovery and other experiments directed toward uncovering fundamental biological mechanisms;
  • How knowledge of these fundamental mechanisms provides a crucial underpinning for more applied studies relevant to human health and disease; and
  • The role of individuals, particularly scientists relatively early in their careers, in making these discoveries.

I presented these themes in the context of two scientific endeavors:

  • The discovery of telomeres and telomerase, recognized by the 2009 Nobel Prize in physiology or medicine; and
  • The elucidation of genetic factors in determining the effective dose of warfarin (Coumadin), one of the early successes in pharmacogenomics.

I greatly enjoyed the opportunity to highlight the impact and importance of the research that NIGMS funds.

Minority Programs Updates

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Minority Opportunities in Research (MORE) LogoI want to let you know about recent changes to our Minority Biomedical Research Support Research Initiative for Scientific Enhancement (MBRS RISE) program and about two upcoming technical assistance workshops.

MBRS RISE Changes

Applicants for this program, which enhances student development at minority-serving institutions, now must select and apply for one of three options based on their institution’s track record of students graduating and pursuing Ph.D.s in the biomedical or behavioral sciences and their number of faculty participating in funded biomedical research as principal investigators. For more information, see the latest program announcement.

Technical Assistance Workshops

These one-day regional workshops led by NIGMS staff will discuss MBRS RISE and a similar program, Minority Access to Research Careers Undergraduate Student Training in Academic Research (MARC-U*STAR). The workshops, which are geared toward individuals who would like to learn more about these programs, will examine the program announcements, offer tips on preparing applications and discuss recent changes in peer review.

  • West Coast Regional Technical Assistance Workshop
    Friday, April 16, 2010
    University of California, Irvine
    (Registration closes April 2)
  • East Coast Regional Technical Workshop
    Friday, April 23, 2010
    LaGuardia Community College
    (Registration closes April 16)

To get other news about NIGMS minority programs and information of interest to participants in these programs, subscribe to the Minority Programs Update e-newsletter.

Register for 2010 Structure and Function Technologies Workshop

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Protein Structure Initiative Meeting Logo

Interested in new methods for improving the speed, cost and success of protein structure determination? Want to learn more about how to use structural and biophysical methods to functionally characterize macromolecules? Then consider attending our 10th annual Enabling Technologies in Structure and Function workshop from April 19-21, 2010, on the NIH campus in Bethesda, MD. There’s no registration fee.

As in years past, the 2010 workshop will cover all the practical issues concerning protein structure determination and biophysical methods. Presentations will focus on topics such as protein structure and function, hybrid methods, bioinformatics and homology modeling, and crystallization methods for soluble proteins and membrane proteins. In addition, we’re offering two hands-on workshops on methods for solving difficult crystallization problems and tools for mining the rich structure and function databases for biological macromolecules. There will also be a poster session.

We build the oral sessions from attendees’ submitted poster abstracts, so we will continue to finalize the agenda in the coming weeks.

The program is very student-friendly, and we welcome scientists involved in structural efforts abroad. Please feel free to forward this note to anyone who may like to attend.

Conversations with the Scientific Community

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One of my activities as NIGMS director is meeting with members of the scientific community, including leadership groups from scientific societies. These conversations offer a valuable forum for sharing ideas and perspectives, and I find them informative and interesting.

A few weeks ago, for example, I met with the board of the Society for Advancement of Chicanos and Native Americans in Science (SACNAS). The group of more than 30 people who visited me in Bethesda ranged from graduate students to senior scientists. We had a spirited dialogue about training and career development, including issues related to the diversity of the scientific workforce, and methods for fostering communication between NIH and the scientific community. I briefly discussed our preparations for a strategic plan on training and career development, which I announced at our recent advisory council meeting.

I’ll do a Feedback Loop post in early March with more details on the strategic planning process, including a request for input.

NIGMS staff and I welcome the opportunity to meet with groups and individuals who would like to know more about the Institute’s activities and plans. To arrange a meeting, feel free to e-mail me at bergj@nigms.nih.gov or NIGMS communications director Ann Dieffenbach at dieffena@nigms.nih.gov.