One of the most common questions we receive about the Maximizing Investigators’ Research Award (MIRA) program is the likelihood of an application’s funding given a certain overall impact score.
Frequent readers of this blog may note that we typically provide statistics as they relate to our R01 portfolio, but we’ve yet to provide a similar “funding curve” for the MIRA program. One reason that MIRA applications haven’t been included in these analyses is that, unlike most R01 applications, MIRA R35 applications don’t receive a percentile score. The percentile score allows for normalization of overall impact scores across study sections to account for any differences in scoring behavior that are observed in review panels. See the Office of Extramural Research’s comprehensive blog post for more information about overall impact scores and percentiles.
Continue reading “Funding Trends: MIRA Applications and Overall Impact Scores”
NIGMS has made MIRA awards to Established Investigators (EI) and Early-Stage Investigators (ESI) for three full Fiscal Years (FY). In this Feedback Loop post, we provide an analysis of application, review, funding, and demographic trends for the MIRA program.
For the first two rounds of EI MIRAs, eligibility was limited to well-funded NIGMS investigators: PIs with two or more NIGMS R01-equivalent awards or one NIGMS R01-equivalent award for >$400,000 in direct costs. For the FY 2018 EI competition and beyond, eligibility was expanded to include any investigator with a single PD/PI NIGMS R01-equivalent that is up for renewal. For the FY 2016 ESI MIRA competition, ESIs and New Investigators (NI) at the assistant professor or equivalent level were eligible, whereas eligibility was restricted to ESIs in subsequent rounds. As always, a PI can apply for an extension of ESI status for various life and career events, including childbirth.
Continue reading “Application, Review, Funding, and Demographic Trends for Maximizing Investigators’ Research Awards (MIRA): FY 2016-2018”
A recent analysis by NIGMS staff has uncovered some promising results for women entering academic positions in the biomedical sciences. The study, which published today in the Proceedings of the National Academy of Sciences (PNAS), found that once men and women receive their first major NIH grant, their funding longevity is similar. The data contradict the common assumption that, across all career stages, women are at a large disadvantage compared to men.
The results of the analysis should be encouraging for women interested in becoming independent investigators, since the likelihood of sustaining NIH grant support may be better than commonly perceived. You can read the full study, “NIH Funding Longevity by Gender,” in the current edition of PNAS.
One question that has been asked about the Maximizing Investigators’ Research Award (MIRA) for Early Stage Investigators is how awardees will be affected by the fact that they cannot have additional NIGMS research grants. In response to this question, we reviewed the research project grant (RPG) funding history of all 707 Principal Investigators (PIs) who received an NIGMS R01 as an Early Stage Investigator (ESI) between Fiscal Years 2009 and 2015. The PIs were grouped by Year of PI, which ranges from Year 1 to Year 5 (five years is the typical length of an ESI R01 award). Year 1 is the year in which the PI was awarded his or her initial R01, and Year 2-Year 5 represent the subsequent years. The awards and funding history of each PI were confined to Fiscal Years 2009-2015; thus, all PIs are included in the Year 1 group, while those who received their initial R01 in 2013, for example, would only appear in the Year 1-Year 3 groups.
The distribution of NIGMS awards (including subprojects) for these PIs is depicted below.
Figure 1. Percentage of Principal Investigators by Number of Active NIGMS Awards. Year 1 represents the year of the initial NIGMS R01; Year 2-Year 5 represent the subsequent years. Only Fiscal Years 2009-2015 are included. No PIs had more than three active NIGMS awards in a single year.
Adding up the percentages of PIs with two and three awards, Figure 1 shows that the percentage of PIs with more than one active NIGMS award ranges from 2.8% in Year 1 to 13.9% in Year 5. Continue reading “A Historical Analysis of NIGMS Early Stage Investigators’ Awards and Funding”
UPDATE: The MIRA FOA for early stage investigators has been reissued.
We have begun making grant awards resulting from responses to RFA-GM-16-003 (R35), the Maximizing Investigators’ Research Award (MIRA) for New and Early Stage Investigators pilot program. We received 320 applications in areas related to NIGMS’ mission, and they were reviewed by four special emphasis panels organized by the NIH Center for Scientific Review. We anticipate making 93 awards, which is more than we estimated in the funding opportunity announcement (FOA); the corresponding success rate is 29.1%.
The awards will be for a 5-year project period, as is typically the case for NIGMS R01 awards to new and early stage investigators. Most awards will be for the requested and maximum amount of $250,000 in annual direct costs, with an average of $239,000 and median of $250,000. In Fiscal Year 2015, NIGMS R01 awards to new or early stage investigators averaged $209,000 in annual direct costs (median of $198,000) and had a 24.4% success rate. During the same period, all competing NIGMS R01 awards averaged $236,000 in annual direct costs (median of $210,000) and had a 28.8% success rate. Thus, the MIRA pilot program had success rates similar to those of comparable R01 applications and offered some direct financial benefit to this group of applicants. We expect other benefits of the MIRA program, including increased funding stability and research flexibility, reductions in time spent writing and reviewing grant applications and improved distribution of NIGMS funding, will accrue among these investigators and the community at large as implementation of the MIRA program continues.
You can find more information about the awards on NIH RePORTER by entering RFA-GM-16-003 in the FOA field; however, the record of funded grants will not be complete until after the end of Fiscal Year 2016 (September 30). Because the initial budget period of MIRA awards will be offset by existing NIGMS grant support from other mechanisms (e.g., career awards), the first-year budget of a MIRA may be lower than the annual funding level used to calculate the average and median amounts shown above. We plan to post a detailed analysis of MIRAs after we have issued all the awards. We’ve previously posted information on NIGMS R01 award sizes and success rates for new and early stage investigators.
As I mentioned in my last post, we’re planning to reissue the MIRA FOA for early stage investigators in the near future.
You can find additional information about the program on our MIRA web page.