Becoming a Peer Reviewer for NIGMS

NIH’s Center for Scientific Review (CSR) is not the only locus for the review of grant applications–every institute and center has its own review office, as well. Here at NIGMS, the Office of Scientific Review (OSR) handles applications for a wide variety of grant mechanisms and is always seeking outstanding scientists to serve as reviewers. If you’re interested in reviewing for us, here’s some information that might help.

Continue reading

Comment on Proposed Framework for NIH-Wide Strategic Plan

NIH is currently gathering input from the scientific community, including stakeholder organizations, on the proposed framework for its 5-year strategic plan. Responses are due by August 16, 2015.

We’ve been asked to share this message from NIH Principal Deputy Director Larry Tabak about the call for comments and suggestions:

In order to advance the NIH mission, the NIH is developing an NIH-wide Strategic Plan. The goal of this 5-year plan is to outline a vision for biomedical research that ultimately extends healthy life and reduces illness and disability. NIH senior leadership and staff have developed a proposed framework for the Strategic Plan that identifies areas of opportunity across all biomedicine and unifying principles to guide NIH’s support of the biomedical research enterprise. The aim is to pursue crosscutting areas of research that span NIH’s 27 Institutes, Centers, and Offices.

I invite you to review the framework in our Request for Information and on the NIH website, and to provide your feedback via the RFI submission site. I encourage stakeholder organizations (e.g., patient advocacy groups, professional societies) to submit a single response reflective of the views of the organization/membership as a whole. We also will be hosting webinars to gather additional input. These webinars will be held in early to mid-August.

Your input is vital to ensuring that the NIH Strategic Plan positions biomedical research on a promising and visionary path. I appreciate your time and consideration in assisting us with this effort.

The webinars Exit icon mentioned in Larry’s message are scheduled for August 3, 5 and 11.

Reproducibility Update: New Resources and Expected Changes to the SF424 Application Guide

I previously told you about the development of an NIGMS clearinghouse site where members of the research community will be able to find grantee-produced training materials designed to teach rigorous experimental design and enhance data reproducibility. Since then, NIH has established two new related sites. The first is a Rigor and Reproducibility web portal that provides general information about NIH efforts and offers resources that include guidelines for how research results should be reported and links to publications written by NIH authors on rigor, reproducibility and transparency.

The second site is focused on grants and funding and includes a summary of NIH’s proposal to clarify its instructions to applicants to emphasize expectations that rigorous experimental design and reproducibility of results should be considered during the application and review process. You may have read about the changes in a recent Rock Talk blog post that announced the publication of two new NIH Guide notices: Enhancing Reproducibility through Rigor and Transparency and Consideration of Sex as a Biological Variable in NIH-funded Research. We anticipate that the new instructions will be released in the fall of 2015 and will take effect for all research grant applications submitted on or after January 25, 2016.

As always, if you have questions or concerns, contact your program director. We’re also interested in hearing how your lab validates key biological and chemical reagents, so tell us about your procedures!

Resource Spotlight: iBiology Videos

In this iBiology video, NIGMS Director Jon Lorsch gives an overview of the Institute and careers in scientific public service. He also answers questions from the scientific community during an iBiology Q&A session.
In this iBiology video, NIGMS Director Jon Lorsch gives an overview of the Institute and careers in scientific public service Exit icon. He also answers questions from the scientific community Exit icon during an iBiology Q&A session.

One of the research and training resources we help fund is iBiology Exit icon, a collection of high-quality, free online videos of scientists talking about their research, career paths and related topics. The project, which also receives support from the National Science Foundation and other organizations, produces material that is relevant to those at a range of educational and career levels, especially undergraduate students, graduate students and postdocs.

When Ron Vale started the iBiology project in 2006, his goal was to give people around the world broader access to research seminars. Since then, the scope has expanded. The collection now includes 350 videos that fall into three main categories:

Continue reading

Outcomes Analysis of the NIGMS Diversity Supplement Program

We recently analyzed outcomes of the NIGMS Research Supplements to Promote Diversity in Health-Related Research (referred to here as the Diversity Supplement Program or DSP), which provides investigators holding active NIGMS research grants with supplemental funds to support scholars from groups underrepresented in biomedical science. Using a public search approach, we could track a large proportion of participants—but not all—through doctoral training and into various careers. We assessed the educational and career outcomes for undergraduate, graduate student and postdoctoral participants supported by supplements between 1989 and 2006, and we encourage you to explore the report.

Continue reading

MIRA Webinar, Other Resources for New and Early Stage Investigators

UPDATE: Due to technical difficulties, the MIRA webinar was not recorded. We have posted the slides on the MIRA Web page, where we’ll also post a summary of the webinar questions and answers.

NIGMS Director Jon Lorsch and I will field questions about the recently announced Maximizing Investigators’ Research Award (MIRA) for New and Early Stage Investigators (R35) during a webinar on Tuesday, June 30, from 1-2 p.m. EDT. Participants will be able to submit questions using the chat feature. We’ll post the archived webinar and slides on the MIRA Web page.

The most common questions we’re getting about the new MIRA funding opportunity announcement (FOA) have concerned eligibility, so we created a new flowchart to help determine this. Another common question has related to research areas appropriate for support by a MIRA. These and other topics are covered in our answers to frequently asked questions about the second MIRA FOA.

If you have colleagues who may be eligible to apply but may not know about the FOA or may have questions about it, please share this post with them.

As with the first MIRA FOA, this competition is an experiment and is intentionally limited to a small group of eligible applicants. If the pilot is successful, we plan to issue future FOAs covering additional groups of investigators.

For more information about the MIRA program, e-mail me or call me at 301-594-0828.

Further Analysis of Renewal Rates for New and Established NIGMS Investigator Projects

In an earlier blog post, I presented data on the first competing renewal rates of R01 projects that NIGMS awarded to new and established investigators. The analysis showed that no renewal application was submitted for a substantial percentage of projects—30% of new projects from new investigators and 45% of new projects from established investigators. This raises questions, such as those suggested by Feedback Loop readers, including:

  • Do projects for which no renewal is submitted generally have less productivity or scientific impact?
  • Are new projects awarded to established investigators more likely to represent the second or third award to that investigator?

I’ve tried to explore these questions in a further analysis.

Continue reading

Requesting Input on the Support of Biomedical Technology Development

NIGMS is in the process of considering how best to support two important activities: the development of biomedical technologies and access to those technologies as they become research resources. These topics are strongly related, but there are aspects of each that should be explored independently. An important part of this process is getting input from the community, so we’ve issued a request for information (RFI) focused on technology development. A subsequent RFI will extend the discussion to the support of research resources.

There are two main issues that we’re thinking hard about right now as we consider how our technology development programs should be structured:

  • The relationship between technology development and question-based biomedical research. We’re particularly interested in whether and how technology development and question-driven research should be coupled in different circumstances. Coupling technology development with addressing biomedical research problems can help ensure the relevance of the tools that emerge, but it may not always be necessary or appropriate.
  • Supporting the full range of biomedical technology development. We’re interested in the effective support of all aspects of technology development, from the exploration of emerging concepts to the conversion of fragile technologies into standard tools.

Continue reading

PRAT Program Marks 50th Year with Scientific Symposium

PRAT Symposium Speakers

Steven Paul, Weill Cornell

Jacqueline Crawley, UCSD

Richard Weinshilboum, Mayo Clinic

Katherine Roche, NIH

James Stevens, Eli Lilly

Jennifer Elisseeff, Johns Hopkins

Jennifer Lippincott-Schwartz, NIH

Elizabeth Grice, U Penn

Robert Ruffolo, Jr., Wyeth (retired)

Henry Bourne, USCF

In the years since the first cohort of postdoctoral fellows entered the NIGMS Pharmacology Research Associate (PRAT) program in 1965, the program’s alumni have become leaders in pharmacology, neuroscience, cell biology and related fields across multiple career sectors, including academia, government and industry. On November 6, we’ll mark the accomplishments of the more than 400 PRAT alumni in a full-day scientific symposium on the NIH campus in Bethesda, MD.

The symposium will feature presentations by 10 alumni spanning the duration of the program and is free and open to the public, although we encourage you to register to attend. If you can’t be there in person, you can watch the event live or later. If you have comments, anecdotes, historical data or photos from the PRAT program, please let us know by writing a note in the comments box on the meeting registration site or by sending me an e-mail message.

Continue reading

Comment on the Need for Support of Membrane Protein Structure Determination

Membrane proteins and large macromolecular assemblies are important targets for understanding cell function and for drug discovery, but their characterization presents unique technical challenges. We’re considering how best to help researchers meet these challenges.

To give the biomedical research community the opportunity to offer comments on this topic, we have just issued a request for information (RFI). We want your opinion on the most effective methods for the determination of membrane protein and large macromolecular assembly structures and/or the need for new tools to aid in structure determination of these proteins or protein complexes.

Continue reading