NIGMS is committed to supporting safety in the nation’s biomedical research and training environments. Last April, we shared with you resources for enhancing lab safety in biomedical research training environments. Now, in a perspective in the current issue of Molecular Biology of the Cell (MBoC), we focus on strategies for improving laboratory safety. Some of these strategies are also applicable to other forms of safety including the prevention of harassment, intimidation, and discrimination. We frame the problem of laboratory safety using a number of recent examples of tragic accidents, highlight some of the lessons that have been learned from these and other events, discuss what NIGMS is doing to address problems related to laboratory safety, and outline steps that institutions can take to improve their safety cultures.
Continue reading “Developing a Culture of Safety in Biomedical Research Training”Category: News
Remembering Former NIGMS Director Marvin Cassman
We in the NIGMS family are deeply saddened by the loss of our former director Marvin Cassman, Ph.D., on August 6. Dr. Cassman joined NIGMS in 1975 as a health scientist administrator in what was then the Cellular and Molecular Basis of Disease Program, advancing through the ranks to become NIGMS’ deputy director, acting director, and from 1996 to 2002, director. Dr. Cassman’s tenure as director coincided with the period of NIH’s budget doubling, and he ably led NIGMS’ establishment of key initiatives that have had a worldwide impact. These included the Protein Structure Initiative, the goal of which was to make the three-dimensional, atomic-level structures of most proteins easily obtainable from knowledge of their corresponding DNA sequences. This enabled investigators to apply the new paradigm of high-throughput structure determination to study important biological and biomedical problems.
Continue reading “Remembering Former NIGMS Director Marvin Cassman”Remembering Ward Smith
I am deeply saddened to tell you that Ward Smith, chief of our Biomedical Technology Branch in the Division of Biophysics, Biomedical Technology, and Computational Biology, passed away at the beginning of July.
Continue reading “Remembering Ward Smith”Lasker Awards Honor Three NIGMS Grantees
We are delighted that three long-time NIGMS grantees have been recognized by the 2018 Lasker Awards . The awards highlight fundamental biological discoveries to draw attention to the importance of public support of science.
- Michael Grunstein of the University of California, Los Angeles, and C. David Allis of Rockefeller University, received the 2018 Albert Lasker Basic Medical Research Award for “discoveries elucidating how gene expression is influenced by chemical modifications of histones—the proteins that package DNA within chromosomes.” NIGMS funded Grunstein’s work on the establishment and spreading of silent chromatin from 1977 to 2012. His research led to the generation of the first histone mutations in yeast and the first demonstration that chemical modification of specific ends of histones could turn gene expression on or off. Allis identified and characterized enzymes that add, remove, and read histone modifications. His work led to the hypothesis of a histone code that, when mis-read, can lead to disease. NIGMS has funded Allis since 1988.
- Joan Argetsinger Steitz of Yale University received the 2018 Lasker-Koshland Special Achievement Award in Medical Science for “four decades of leadership in biomedical science—exemplified by pioneering discoveries in RNA biology, generous mentorship of budding scientists, and vigorous and passionate support of women in science.” Steitz’s pioneering research helped reveal the function of small pieces of RNA that are not used for making proteins. These molecules, including small nuclear ribonucleoproteins (snRNPs), help regulate gene activity. In doing so, they—like histone modifications—have a major impact on health and disease. NIGMS funded her research from 1975 to 2014. The Lasker-Koshland Award further recognizes Steitz’s long record of mentoring the next generation of scientific leaders and her effective and tireless work as an advocate for women in science.
We congratulate all of the recipients on these well-deserved honors.