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P01 Outcomes Analysis

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As part of our program assessment process, we have analyzed NIGMS program project (P01) grants to improve our understanding of how their outcomes compare with those of other mechanisms.

The most recent NIGMS funding opportunity announcement for P01s states that individual projects “must be clearly interrelated and synergistic so that the research ideas, efforts, and outcomes of the program as a whole will offer a distinct advantage over pursuing the individual projects separately.” From this perspective, we sought to address three major questions:

  • Do P01s achieve synergies above and beyond a collection of separate grants?
  • How do the results from P01s compare with those from R01s?
  • Do certain fields of science need P01s more than others?

To address these questions, we analyzed the outcomes of P01 grants using several different metrics and compared these outcomes to those of two comparator groups: single-principal investigator (PI) R01s and multiple-PI R01s. Since P01s could be considered as a collection of single-PI R01s and one or more cores, we chose single-PI R01s as a comparator group. Because a major facet of P01s is their focus on using collaborative approaches to science, we also wanted to compare their outcomes to another collaboration-focused research grant: multiple-PI R01s. While structurally different from P01s, multiple-PI R01s allow for a comparison between two competing models of funding team science within the NIGMS portfolio.

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First Awards Issued in MIRA Pilot Program

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We have begun making grant awards resulting from responses to RFA-GM-16-002 (R35), the Maximizing Investigators’ Research Award (MIRA) pilot program. Out of the 179 applications we received, we have so far authorized 123 awards. The median yearly direct costs for these grants is $399,842, and the mean is $405,884. For comparison, the median yearly direct costs for an NIGMS R01 in Fiscal Year 2015 was $210,000, and the mean was $237,254.  On average, the budgets of these MIRAs to established investigators were reduced by 12% relative to the investigators’ recent NIGMS funding history. As described in the funding opportunity announcement (FOA), the budget reductions were in exchange for the benefits of the program: a 5-year award instead of the standard 4-year one, increased flexibility to follow new research directions, increased funding stability and decreased administrative burden. We will use the funds freed up through this trade-off to support other investigators and improve the distribution of NIGMS funding. It will take time for the full benefits of the program to individual investigators and the research community to become clear.

You can find more information about these awards on NIH RePORTER by entering RFA-GM-16-002 in the FOA field; however, the record of funded grants will not be complete until the end of Fiscal Year 2016. Because merging an investigator’s previous funding into a single award presents a variety of complications, in some cases the first-year budget of the MIRA is lower than the eventual funding level will be. This is frequently the case when the principal investigator (PI) was part of multi-PI grants that will be allowed to end before all NIGMS funding for the investigator is put on the MIRA or when the PI had already received funds from NIGMS in the current fiscal year.

We will begin making awards for the new and early stage investigators MIRA (RFA-GM-16-003) after the May 19-20 meeting of the National Advisory General Medical Sciences Council.

You can find additional information about the program on our MIRA web page.

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Give Input on the Support of Biomedical Research Resources

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NIGMS is considering how best to support two important activities: the development of biomedical technologies and access to those technologies as they become research resources. These topics are closely related, but there are aspects of each that should be explored independently.

Last summer, the Institute issued a request for information (RFI) on the support of biomedical technology development. The responses we received contributed significantly to initiatives for exploratory and focused technology development to be launched later this year. We now request your input in response to a new RFI on the need for and support of research resources (NOT-GM-16-103).

We’d like to know your thoughts on a number of topics, including:

  • The appropriateness and usefulness of existing research resources to the biomedical research community.
  • Examples of unmet needs for research resources.
  • The relative value of resources that serve many investigators versus specialized resources used by fewer investigators.
  • The value and manner of coupling technology development to research resources.
  • The review of research resource applications and the evaluation of funded projects.
  • The role of academia, other biomedical institutions and industry in developing and providing access to research resources.
  • The role of investigators and user fees in supporting institutional, regional and national resources.
  • The role of NIGMS in supporting research resources and technology development at various levels.

We also welcome any other comments that you feel are relevant to supporting research resources.

To respond to this RFI, send an email to nigmsresource@mail.nih.gov by June 3, 2016.

If you have any questions about the RFI, please let us know.

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Wanted: Program Directors for Predoctoral and Postdoctoral Training, Capacity-Building Programs

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We’re looking for multiple program directors (also known as program officers or health scientist administrators) to manage research grants, undergraduate and/or graduate student research and postdoctoral career development programs, and capacity-building programs.

Several of the positions are in the Undergraduate and Predoctoral Training Branch of our Division of Training, Workforce Development, and Diversity (TWD). These individuals will manage undergraduate and/or graduate student development programs along with research and training grants. Another position is in TWD’s Postdoctoral Training Branch. This individual will manage one or more of the programs in this branch along with research and training grants. We’re particularly interested in candidates who have broad expertise in areas relevant to the NIGMS mission and professional experience in the training of research scientists as well as in programs aimed at increasing the diversity of the scientific workforce.

The other position is in our Center for Research Capacity Building. This individual will manage programs that support research and provide resources for research infrastructure enhancement and capacity building in the basic, translational and clinical biomedical sciences. These programs seek to enhance the competitiveness and diversity of the biomedical research workforce.

Please see the vacancy announcement for position descriptions and requirements and detailed application procedures. The positions close on April 13.

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New Early Career Investigator Lecture for Undergraduate Students

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Blake WiedenheftI’m very pleased to announce a new annual lecture to highlight the achievements of some of NIGMS’ early career grantees.

The first NIGMS Director’s Early Career Investigator Lecture will be given by Blake Wiedenheft, Ph.D., an assistant professor in the Department of Microbiology and Immunology at Montana State University who does research on the CRISPR gene-editing system. His talk, “Bacteria, Their Viruses, and How They Taught Us to Perform Genome Surgery,” will take place on Wednesday, April 13 from 2:00-3:00 p.m. EDT on the NIH campus. The lecture will be videocast and archived on the NIH Videocasting site.

Although open to everyone in the scientific community, this and future talks in the series will be geared toward undergraduate students. After describing their research, speakers will discuss their career paths during a 30-minute question-and-answer session.

We’re hopeful that these lectures will help inform participants about cutting-edge areas of science and inspire them to pursue biomedical research careers. I encourage you to tell your students about this opportunity to ask Blake career-related questions. They can send their questions by email to Jilliene Drayton before Monday, April 11, or tweet them with the hashtag #ecilecture.

Editor’s Note: An archived video of the lecture, including the question-and-answer session, is on the NIH Videocasting and Podcasting site.

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Five Reasons to Submit a Cover Letter with Your Grant Application

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I recently attended a scientific meeting where I had the opportunity to talk with investigators at all stages of their scientific careers. I was surprised to learn that many didn’t know that they could submit a cover letter with their electronic grant application. Here I briefly explain some reasons to provide a cover letter, including situations that require one.

1. Suggest a particular review group for your application.

The NIH Center for Scientific Review (CSR) assigns applications to scientific review groups (SRGs), but sometimes an application could be a scientific match for more than one study section. In a cover letter, you can request assignment to a particular study section and explain why you think that study section would be the best fit. Appropriate assignment requests are honored in the majority of cases. Study section descriptions, recent study section rosters and the NIH RePORTER database of funded grants can help you identify an SRG suitable for your application.

2. Suggest a particular institute or center (IC) for funding your research.

Your research might be relevant to the mission of more than one NIH IC. You can use a cover letter to suggest that your application be assigned to a specific IC. The NIH RePORTER database is a good place to investigate the types of research supported by different ICs. Before making a request in a cover letter, you should also consult with program officers at the IC to determine whether your application would be an appropriate scientific match.

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Application and Funding Trends

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The Consolidated Appropriations Act, 2016, provides funding for the Federal Government through September 30. NIGMS has a Fiscal Year 2016 appropriation of $2.512 billion, which is $140 million, or 5.9%, higher than it was in Fiscal Year 2015. With this opportunity to expand NIGMS support for fundamental biomedical research comes a responsibility to make carefully considered investments with taxpayer funds.

Application Trends

One of the most commonly cited metrics when discussing grants is success rate, calculated as the number of applications funded divided by the number of applications received. As shown in Figure 1, the success rate for NIGMS research project grants (RPGs) increased from 24.8% in Fiscal Year 2014 to 29.6% in Fiscal Year 2015. This was due to an increase in the number of funded competing RPGs as well as a decline in the number of competing RPG applications. In contrast, in Fiscal Year 2013, applications increased while awards decreased, leading to a notable decrease in success rate. Overall, we have seen a decrease in RPG applications over the last 2 years, a trend warranting additional investigation.

Figure 1. Number of NIGMS Competing RPG Applications, Funded Competing RPGs and Success Rates for RPGs, Fiscal Years 2004-2015. NIGMS RPG applications (blue circles, dashed line; left axis) decreased from Fiscal Years 2014 to 2015 to a 5-year low. Meanwhile, NIGMS-funded RPGs (green squares, solid line; left axis) increased in Fiscal Year 2015 to a level not seen since Fiscal Year 2007. As a result, the NIGMS RPG success rate (gray triangles, dotted line; right axis) was the second highest it has been in the past decade.
Figure 1. Number of NIGMS Competing RPG Applications, Funded Competing RPGs and Success Rates for RPGs, Fiscal Years 2004-2015. NIGMS RPG applications (blue circles, dashed line; left axis) decreased from Fiscal Years 2014 to 2015 to a 5-year low. Meanwhile, NIGMS-funded RPGs (green squares, solid line; left axis) increased in Fiscal Year 2015 to a level not seen since Fiscal Year 2007. As a result, the NIGMS RPG success rate (gray triangles, dotted line; right axis) was the second highest it has been in the past decade.
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New NIGMS Initiatives for Supporting Technology Development

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The January 2016 Advisory Council meeting presentation on the initiatives begins at 1:14:43

The January 2016 Advisory Council meeting presentation on the initiatives begins at 1:14:43.

We would like to tell you about two new technology development initiatives recently approved by our Advisory Council. These programs are part of an ongoing effort that we’ve previously described to facilitate early stage, investigator-initiated work to create or improve tools for biomedical research.

Developing and providing access to technologies that enable biomedical research is a high priority for NIGMS, as expressed in our 2015 strategic plan. Historically, support for technology development has generally been coupled to using the technology to answer a biomedical research question. Although in the later stages of technology development this coupling is often useful, in the early stages it can hinder exploration of innovative ideas that could ultimately have a big impact on research.

We think the two initiatives briefly described below will stimulate early stage technology research and development by allowing scientists to focus on making the technology work before they begin to apply those tools to biomedical research questions.

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Webinar for MARC U-STAR Program Applicants

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UPDATE: The slides from the MARC U-STAR program applicant Webinar have been posted.

If you are preparing an institutional MARC U-STAR grant application, you might have questions about the funding opportunity announcement, data tables and FORMS-D package required for the upcoming May 25 receipt date. We will be available to discuss these topics during a webinar on Thursday, April 7, from 3:15-4:45 p.m. EDT. You may send questions to me before the webinar or post them in the chat box during the event.

To access the webinar, visit the WebEx Meeting page and enter meeting number 622 362 803 and the password “NIGMS.” If you are unable to attend online, you can join by phone by calling 1-877-668-4493 from anywhere in the United States or Canada and entering the meeting number above.

We look forward to talking to you about the MARC U-STAR program.

NIGMS Staff Participating in April 7 Webinar

Alison Gammie, Director, Division of Training, Workforce Development, and Diversity

Shiva Singh, Chief, Undergraduate and Predoctoral Training Branch, Division of Training, Workforce Development, and Diversity

Richard Okita, Program Director, Division of Pharmacology, Physiology, and Biological Chemistry

Sailaja Koduri, Scientific Review Officer (on detail from NCATS), Division of Training, Workforce Development, and Diversity

Mona Trempe, Scientific Review Officer, Office of Scientific Review

Justin Rosenzweig, Grants Management Specialist, Division of Extramural Activities

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Educational Outcomes of the NIGMS Maximizing Access to Research Careers Undergraduate Student Training in Academic Research (MARC U-STAR) Program

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UPDATE: The MARC U-Star report includes an addendum on the demographics of the program’s alumni.

We recently analyzed the educational outcomes of trainees who participated in the NIGMS MARC U-STAR program. The goal of the program is to enhance the pool of students from underrepresented groups earning baccalaureate and Ph.D. degrees in biomedical research fields. MARC U-STAR is part of a larger effort at NIGMS to support the development of a highly skilled, creative and diverse biomedical research workforce [PDF]. This study was designed to identify the educational outcomes of over 9,000 MARC U-STAR alumni appointed at 114 institutions between 1986 and 2013.

MARC U-STAR grants are awarded to undergraduate institutions. Each grant supports a continuous 2-year program for the junior and senior (or final two) years of college that provides the trainees with academic enhancement, research training and professional skills development. In addition to these on-campus enhancements, MARC U-STAR institutions are expected to provide each trainee with a summer research experience at a research-intensive institution. The recently released Funding Opportunity Announcement describes the expectation that a majority of MARC U-STAR alumni nationwide will matriculate in a research doctorate program.

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