We’re pleased to announce the launch of MyNRMN , a free, web-based platform designed to help biomedical researchers and students across the United States connect professionally. MyNRMN is part of the National Research Mentoring Network , which NIGMS manages for the NIH Common Fund’s Diversity Program Consortium.
MyNRMN is designed for scientists at every career level. Faculty in more senior roles and established researchers can sign up as mentors. Early career faculty can serve as mentors or be mentees, depending on their needs. Undergraduates, graduate students and postdocs can elect to be peer mentors or sign up to be mentored. The connections you form through MyNRMN might be as simple as asking a question to scheduling formal mentoring sessions.
Some of MyNRMN’s features include:
- Browsing other registrants’ profiles to connect with people who have similar interests (as on social media sites).
- Sharing documents and sending direct messages to your connections.
- Creating a personalized calendar to schedule mentee/mentor meetings, and electing whether you would like to receive text message reminders.
- Revising and improving your resume with the CV Builder tool (for mentees).
Not long ago, Jon Lorsch and I and several other NIGMS staff met with the leadership of one of the professional societies that represents many of our grantees. It was an opportunity to discuss NIGMS’ policies and grant mechanisms, hear about challenges that investigators face, and share ideas about how the biomedical research and training environment can be improved.
Meetings of this kind are not unusual, but they are just one of the ways we interact with the society partners related to NIGMS’ mission and, through them, communicate with their members. Another way is by attending the societies’ scientific meetings, where our staff learn about the latest research in the field, conduct grantsmanship workshops, and answer questions about the funding process.
The professional societies help us disseminate—and receive—information. For instance, they share our notices about funding opportunities and changes in NIH policies as well as respond to our requests for information. Leadership from the professional societies attend the open sessions of our Advisory Council meetings and sometimes speak during the public comment period, enhancing the exchange of information between the Institute and our constituency.
We also collaborate with professional societies on specific activities. Recent examples include meetings convened by FASEB on rigor and reproducibility and by ASBMB on research training. With ASCB, we co-organized the Life: Magnified exhibit, which brought biomedical science to a public place.
We greatly value our interactions with the societies and invite suggestions for additional ways we can partner.
This blog is one way that we reach out to the scientific community with information about research and research training policies, funding opportunities, analyses, resources, meetings and other useful news. It’s also a key way in which we get your input on our activities and plans.
When I looked back at some recent posts, I was struck by how many of them are relevant to the graduate students and postdocs in your labs. For example, the post describing our plans to modernize graduate education is a must-read for graduate students, whose ideas and perspective will further inform our efforts. The post on talking to NIH staff about your application and grant provides essential information for postdocs who will soon be independent investigators.
Please encourage your students and postdocs to subscribe to the Feedback Loop as well as to send us their suggestions for topics to cover in future posts.
During the life of your application and grant, you’re likely to interact with a number of NIH staff members. Who’s the right person to contact—and when and for what? Here are some of the answers I shared during a presentation on communicating effectively with NIH at the American Crystallographic Association annual meeting. The audience was primarily grad students, postdocs and junior faculty interested in learning more about the NIH funding process.
The three main groups involved in the application and award processes—program officers (POs), scientific review officers (SROs) and grants management specialists (GMSs)—have largely non-overlapping responsibilities. POs advise investigators on applying for grants, help them understand their summary statements and provide guidance on managing their awards. They also play a leading role in making funding decisions. Once NIH’s Center for Scientific Review (CSR) assigns applications to the appropriate institute or center and study section, SROs identify, recruit and assign reviewers to applications; run study section meetings; and produce summary statements following the meetings. GMSs manage financial aspects of grant awards and ensure that administrative requirements are met before issuing a notice of award.
How do you identify the right institute or center, study section and program officer for a new application? Some of the more common ways include asking colleagues for advice and looking at the funding sources listed in the acknowledgements section of publications closely related to your project. NIH RePORTER is another good way to find the names of POs and study sections for funded applications. Finally, CSR has information on study sections, and individual institute and center websites, including ours, list contacts by research area. We list other types of contact information on our website, as well.
The 15-year Protein Structure Initiative (PSI) ended on June 30, 2015. In preparation for the termination of the program, an external committee of structural biologists and biomedical researchers identified high-priority areas for NIGMS’ future support of structural biology and the preservation of certain PSI resources. Here are some of their key recommendations and what we’re planning to do in response.
Continue to support synchrotron beamlines for macromolecular crystallography.
Recognizing the importance of synchrotron beamlines in modern structural biology, we intend to continue to support these community resources. Part of this effort includes using a new funding approach to ensure that NIH-supported investigators have reliable access to mature synchrotron-based resources.
Maintain the technologies that make structural investigations possible at the most advanced level; meet the need for modern cryo-electron microscopy resources.
We’ll continue to use existing grant mechanisms to support structural biology research, including
X-ray crystallography, NMR, cryo-EM and integrative or hybrid methods. To facilitate the use of
cryo-EM for structure determination we have started a program to provide support for consortia of
cryo-EM labs to upgrade their facilities. NIGMS is also developing plans for establishing regional
cryo-EM centers that could provide access to state-of-the-art cryo-EM resources for the broader structural biology community.
On November 5, we’ll host my favorite NIGMS science education event: Cell Day! As in previous years, we hope this free, interactive Web chat geared for middle and high school students will spark interest in cell biology, biochemistry and research careers. Please help us spread the word by letting people in your local schools and communities know about this special event and encouraging them to register. It runs from 10 a.m. to 3 p.m. EST and is open to all.
As the moderator of these Cell Day chats, I’ve fielded a lot of great questions, including “Why are centrioles not found in plant cells?” and “If you cut a cell in half and then turn it upside down will the nucleus, ribosomes, and other parts of the cell fall out?” It’s always amazing to hear what science students are thinking or wondering about. I’m looking forward to seeing what fantastic questions we’ll get this year!
At its September 2015 meeting, our Advisory Council endorsed a concept for funding existing NIGMS-supported synchrotron resources in which the technologies have become mature. This plan will align the funding mechanism used to support the beamlines with the goal of ensuring reliable access to these essential resources for structural biology.
In place of the variety of mechanisms we currently use, we intend to issue a funding opportunity announcement (FOA) called Mature Synchrotron Resources (P30) for 5-year, renewable grants in the range of $1-3 million per year in direct costs. The Institute intends to maintain overall support for mature beamline facilities at the same level it has in the past, but to replace the previous constellation of funding mechanisms with a single, more coherent one.
The focus of the FOA will be on user access, training and support in data collection, processing and analysis. Peer review will assess the resources primarily on their ability to meet the research needs of the user community and on the impact the resources have on their users’ scientific productivity. To ensure that the beamlines maintain their state-of-the-art operations, the FOA will also include support for a limited amount of technology development and implementation.
Since the goal of the effort is to improve the stability of current NIGMS-supported synchrotron structural biology resources for community use, the initial funding opportunity will be open only to synchrotron-based resources already supported by NIGMS.
We welcome your input and feedback on these plans. You can email your comments to me or post them here.
Charles Edmonds, Susan Gregurick, Ward Smith and Mary Ann Wu contributed to this blog post.
I previously told you about the development of an NIGMS clearinghouse site where members of the research community will be able to find grantee-produced training materials designed to teach rigorous experimental design and enhance data reproducibility. Since then, NIH has established two new related sites. The first is a Rigor and Reproducibility web portal that provides general information about NIH efforts and offers resources that include guidelines for how research results should be reported and links to publications written by NIH authors on rigor, reproducibility and transparency.
The second site is focused on grants and funding and includes a summary of NIH’s proposal to clarify its instructions to applicants to emphasize expectations that rigorous experimental design and reproducibility of results should be considered during the application and review process. You may have read about the changes in a recent Rock Talk blog post that announced the publication of two new NIH Guide notices: Enhancing Reproducibility through Rigor and Transparency and Consideration of Sex as a Biological Variable in NIH-funded Research. We anticipate that the new instructions will be released in the fall of 2015 and will take effect for all research grant applications submitted on or after January 25, 2016.
As always, if you have questions or concerns, contact your program director. We’re also interested in hearing how your lab validates key biological and chemical reagents, so tell us about your procedures!
One of the research and training resources we help fund is iBiology , a collection of high-quality, free online videos of scientists talking about their research, career paths and related topics. The project, which also receives support from the National Science Foundation and other organizations, produces material that is relevant to those at a range of educational and career levels, especially undergraduate students, graduate students and postdocs.
When Ron Vale started the iBiology project in 2006, his goal was to give people around the world broader access to research seminars. Since then, the scope has expanded. The collection now includes 350 videos that fall into three main categories:
If you use genetically modified mice or work on a gene in another model organism for which a homolog exists in mice, the Knockout Mouse Phenotyping Program (KOMP2) may benefit your research. It’s a resource that generates mice carrying specific genetic mutations and systematically phenotypes them according to uniform, high quality-control standards.
KOMP2 targets a range of phenotypes in order to improve the chances of gaining preliminary insights into the function(s) of genes that influence multiple traits, including targeting genes for which no information is currently available. The resource also captures negative results and disseminates them broadly. It examines male and female mice and provides data down to the individual mouse level.